Family history and dysplastic nevi increased risk for multiple primary melanomas after an initial melanoma

May 2006
ACP Journal Club;May/Jun2006, Vol. 144 Issue 3, p77
Academic Journal
The article presents information on a study on clinicopathological features of and risk factors for multiple primary melanomas (MPMs). This study aims to find out the factors that increase risk for MPMs in patients with an initial primary melanoma. In the study 4484 patients were diagnosed with an initial primary, however patients with recurrences and who had distant metastases were excluded. It is found that positive family history and presence of dysplastic nevi substantially increase risk for multiple primary melanomas.


Related Articles

  • Identification of cells initiating human melanomas. Schatton, Tobias; Murphy, George F.; Frank, Natasha Y.; Yamaura, Kazuhiro; Waaga-Gasser, Ana Maria; Gasser, Martin; Qian Zhan; Jordan, Stefan; Duncan, Lyn M.; Weishaupt, Carsten; Fuhlbrigge, Robert C.; Kupper, Thomas S.; Sayegh, Mohamed H.; Frank, Markus H. // Nature;1/17/2008, Vol. 451 Issue 7176, p345 

    Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for tumour growth, have been identified in human haematological malignancies and solid cancers. If such minority populations are associated with tumour progression in human patients, specific targeting of...

  • αvβ3 expression on blood vessels and melanoma cells in primary lesions; differential association with tumor progression and clinical prognosis. Kageshita, Toshiro; Hamby, Carl V.; Hirai, Shunji; Kimura, Toru; Ono, Tomomichi; Ferrone, Soldano // Cancer Immunology, Immunotherapy;Jul2000, Vol. 49 Issue 6, p314 

    The αvβ3 integrin has emerged as a key mediator in angiogenesis. Its role in tumor-induced angiogenesis is supported by its up-regulation in vivo in the vasculature of a number of different types of carcinoma. The potential clinical significance of αvβ3 expression on blood vessels in...

  • Family history and dysplastic nevi increased risk for multiple primary melanomas after an initial melanoma: COMMENTARY. McCarthy, William // ACP Journal Club;May/Jun2006, Vol. 144 Issue 3, p77 

    The article presents the author's views regarding a study related to multiple primary melanomas (MPM). The study includes a comprehensive literature review and confirms that second primary melanomas are more common in the same region of the body as the initial melanoma. It is estimated that the...

  • Pseudomesothelioma resulting from metastatic malignant melanoma. Luckraz, Heyman; Morgan, Matt; Gibbs, Allen R.; Butchart, Eric G. // European Journal of Cardio-Thoracic Surgery;Oct2005, Vol. 28 Issue 4, p655 

    Abstract: Isolated pleural metastatic melanoma is an uncommon clinical condition. Clinical diagnosis can be difficult and therapeutic options are limited. We describe a case where there was isolated pleural metastasis, 10 years following complete excision of a superficial melanotic lesion, which...

  • Determinants of survival in patients with brain metastases from cutaneous melanoma. Staudt, M.; Lasithiotakis, K.; Leiter, U.; Meier, F.; Eigentler, T.; Bamberg, M.; Tatagiba, M.; Brossart, P.; Garbe, C. // British Journal of Cancer;4/12/2010, Vol. 102 Issue 8, p1213 

    Background:This retrospective study aimed to identify prognostic factors in patients with brain metastases from cutaneous melanoma.Methods:In all, 265 patients under regular screening according to valid national surveillance guidelines were included in the study. Kaplan–Meier analyses...

  • Primary pulmonary malignant melanoma: a clinicopathologic study of two cases. Li Gong; Xiao-Yan Liu; Wen-Dong Zhang; Shao-Jun Zhu; Li Yao; Xiu-Juan Han; Miao Lan; Yan-Hong Li; Wei Zhang // Diagnostic Pathology;2012, Vol. 7 Issue 1, p123 

    Abstract: Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are very rare. To our knowledge, about 30 cases have been reported in the English literature, one of which involved multiple brain metastases. Here, we report two cases of...

  • Prognostic Factors in Metastatic Melanoma Patients Treated with Biochemotherapy and Maintenance Immunotherapy. MINOR, DAVID R.; MOORE, DAN; KIM, CHRISTINE; KASHANI-SABET, MOHAMMED; VENNA, SURAJ S.; WEI WANG; BOASBERG, PETER; O'DAY, STEVEN // Oncologist;Oct2009, Vol. 14 Issue 10, p995 

    Background. With no U.S. Food and Drug Administration- approved standard therapy other than high-dose interleukin-2 and dacarbazine for metastatic melanoma, biochemotherapy has shown promise, with longterm survival in selected patients. We felt that the study of prognostic factors would...

  • RESPONSE. Landi, Maria Teresa; Kanetsky, Peter; Goldstein, Alisa; Pfeiffer, Ruth // JNCI: Journal of the National Cancer Institute;1/18/2006, Vol. 98 Issue 2, p145 

    The article presents a response on a comment by M.C. Fargnoli and colleagues about the association of melanocortin-1 receptor gene variants with melanoma risk. The author explained that the different estimates for melanoma risk and pigmentation among subjects carrying any variant or nonred hair...

  • Clinical Review: Malignant melanoma.  // GP: General Practitioner;6/6/2012, p20 

    The article presents information on primary cutaneous malignant melanoma (MM), which generally affects fair-skinned individuals. The incidence of MM is increasing because of an increase in risk-prone behavior, better detection and the possibility of overdiagnosis. Ultra violet (UV) radiation...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics