Initial combination therapy with prednisone or infliximab improved outcomes in early rheumatoid arthritis more than DMARDs alone: COMMENTARY

York, Michael; Hunter, David J.
May 2006
ACP Journal Club;May/Jun2006, Vol. 144 Issue 3, p72
Academic Journal
The article presents the author's views regarding a study on the clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (RA). Aggressive treatment of early RA has been shown to limit functional disability and radiographic progression. Many rheumatologists begin therapy of early RA with either sequential substitution monotherapy or with step-up, add-on therapy. The author states that aggressive combination therapy, including either prednisone or infliximab, results in earlier functional improvement and diminishes radiographic progression in patients.


Related Articles

  • Rheumatoid arthritis and cardiovascular disease risk. Newson, Louise // GP: General Practitioner;10/16/2009, p51 

    The article offers information on research on rheumatoid arthritis (RA) and associated cardiovascular disease risk. One analysis showed that rheumatoid arthritis is associated with a 50 percent increase in risk of cardiovascular death. Increased inflammation associated with RA appears to...

  • COMMENTARY: Review: Anti-tumor necrosis factor antibody therapy for rheumatoid arthritis increases risk for serious infection and malignancy. Shoor, Stanford // ACP Journal Club;Nov/Dec2006, Vol. 145 Issue 3, p65 

    The article presents the author's comments on a medical study on anti-tumor necrosis factor (anti-TNF) antibody therapy for rheumatoid arthritis. The study revealed that the antibody therapy for rheumatoid arthritis increases risk for serious infection and malignancy. But the author says that...

  • Eight versus 16-week re-evaluation period in rheumatoid arthritis patients treated with leflunomide or methotrexate accompanied by moderate dose prednisone. Fiehn, C.; Jacki, S.; Heilig, B.; Lampe, M.; Wiesmüller, G.; Richter, C.; Röther, E.; Rochel, E.; Gao, I. // Rheumatology International;Aug2007, Vol. 27 Issue 10, p975 

    In a step-up approach of DMARD treatment of RA a fast response and an early DMARD switch in the case of non-response is important. Therefore, we performed an open trial in which we compared an 8-week and a 16-week observation period during treatment of RA with MTX or LEF, both given in...

  • Co-occurrence of subchondral insufficiency fracture of the femoral head and contralateral femoral neck fracture in a rheumatic patient receiving steroid treatment. Miyanishi, Keita; Hara, Toshihiko; Hamada, Tetsuo; Maekawa, Masayuki; Tsurusaki, Susumu; Moro-oka, Taka-aki; Kamo, Yoshi; Jingushi, Seiya; Torisu, Takehiko // Modern Rheumatology (Springer Science & Business Media B.V.);Dec2008, Vol. 18 Issue 6, p619 

    We describe a 79-year-old woman with rheumatoid arthritis who suffered from subchondral insufficiency fracture of the femoral head (SIF) and contralateral femoral neck fracture. Radiographs obtained two months after the onset of thigh pain showed collapse of the right femoral head and...

  • NOD2 allele variants in patients with rheumatoid arthritis. Pawlik, Andrzej; Kurzawski, Mateusz; Gawronska-Szklarz, Barbara; Drozdzik, Marek; Herczynska, Magdalena // Clinical Rheumatology;Jun2007, Vol. 26 Issue 6, p868 

    Recent reports have proven the importance of genetic factors and inflammation in the pathogenesis of rheumatoid arthritis (RA). In the current study, the frequency of NOD2/CARD15 gene variants (R702W, G908R, and L1007fsinsC) was examined in a group of 243 RA patients and 220 healthy controls....

  • Study: Be more selective when testing for rheumatoid factor.  // Geriatrics;Mar1993, Vol. 48 Issue 3, p21 

    The article reports on a study citing careful measures to be taken for rheumatoid factor testing. Researchers reported that although the diagnostic utility of rheumatoid factor may be limited, its usefulness may improve when the test in ordered selectively. In a study of 86 patients with a...

  • Research brief: RA not a hearing loss risk.  // GP: General Practitioner;3/10/2006, p8 

    The article focuses on a study conducted by researchers from the Mayo Clinic in Rochester, Minnesota, according to which patients with rheumatoid arthritis (RA) are no more likely to develop hearing loss than other patients of the same age. The study compared hearing loss rates in 29 RA patients...

  • Efficacy and safety of the human anti-IL-1beta monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, phase II, dose-finding study.  // BMC Musculoskeletal Disorders;2011, Vol. 12 Issue 1, p153 

    The article presents information on a study that investigated the efficacy and safety of canakinumab in patients with rheumatoid arthritis (RA). The patients were undergoing therapy with doses of methotrexate. The study found that the addition of canakinumab improved therapeutic responses among...

  • Treatment.  // Annals of Internal Medicine;7/6/2010, Vol. 153 Issue 1, pITC1.5 

    The article presents questions and answers related to the treatment of rheumatoid arthritis (RA), including the overall approach to drug therapy in RA, the implication of disease-modifying antirheumatic drugs (DMARDs) to patients and when should biological therapy be considered.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics