Initial combination therapy with prednisone or infliximab improved outcomes in early rheumatoid arthritis more than DMARDs alone

May 2006
ACP Journal Club;May/Jun2006, Vol. 144 Issue 3, p72
Academic Journal
The article presents information on a study on the clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (RA). The study included 508 patients with a history of no previous treatment with a disease-modifying antirheumatic drug (DMARD). It is found that in patients with early RA, initial treatment with prednisone or infliximab in combination with DMARDs resulted in less joint damage and better functional outcome than sequential monotherapy or step-up combination therapy with DMARDs alone.


Related Articles

  • Measures of Rheumatoid Arthritis Disease Activity in Australian Clinical Practice. Taylor, Andrew; Bagga, Hanish // ISRN Rheumatology;2011, Special section p1 

    Objectives. To investigate which rheumatoid arthritis (RA) disease activity measures are being collected in patients receiving glucocorticoids, non-biologic or biologic disease-modifying antirheumatic drugs (DMARDs) in Australian rheumatology practice. Methods. A retrospective audit of medical...

  • Cost-effectiveness modeling of abatacept versus other biologic agents in DMARDS and anti-TNF inadequate responders for the management of moderate to severe rheumatoid arthritis. Russell, Anthony; Beresniak, Ariel; Bessette, Louis; Haraoui, Boulos; Rahman, Proton; Thorne, Carter; Maclean, Ross; Dupont, Danielle // Clinical Rheumatology;Apr2009, Vol. 28 Issue 4, p403 

    To assess the cost-effectiveness of abatacept compared to different biologic treatment strategies for moderate to severe rheumatoid arthritis based on current medical practices in Canada. A model was constructed to assess the cost-effectiveness of various biologic treatments over a 2-year time...

  • Most people over age 50 in the general population do not meet ACR remission criteria or OMERACT minimal disease activity criteria for rheumatoid arthritis. Sokka, T.; Mäkinen, H.; Hannonen, P.; Pincus, T. // Rheumatology;Jun2007, Vol. 46 Issue 6, p1020 

    Objective. To analyse the proportion of individuals in the general population over age 50 who do not meet American College of Rheumatology (ACR) criteria for rheumatoid arthritis (RA) remission, and OMERACT criteria for minimal disease activity (MDA), and to compare results to RA patients.

  • Co-occurrence of subchondral insufficiency fracture of the femoral head and contralateral femoral neck fracture in a rheumatic patient receiving steroid treatment. Miyanishi, Keita; Hara, Toshihiko; Hamada, Tetsuo; Maekawa, Masayuki; Tsurusaki, Susumu; Moro-oka, Taka-aki; Kamo, Yoshi; Jingushi, Seiya; Torisu, Takehiko // Modern Rheumatology (Springer Science & Business Media B.V.);Dec2008, Vol. 18 Issue 6, p619 

    We describe a 79-year-old woman with rheumatoid arthritis who suffered from subchondral insufficiency fracture of the femoral head (SIF) and contralateral femoral neck fracture. Radiographs obtained two months after the onset of thigh pain showed collapse of the right femoral head and...

  • Genotype-based dosing strategy for azathioprine valid in RA, SLE.  // PharmacoEconomics & Outcomes News;3/13/2004, Issue 448, p5 

    Discusses research being done on a genotype-based dosing strategy with azathioprine for the treatment of rheumatoid arthritis or systemic lupus erythematosus. Reference to a study by A. H. Anis and colleagues published in a February 2004 issue of "Rheumatology"; Analysis of thiopurine...

  • Depresión en pacientes con enfermedades autoinmunes más frecuentes en reumatología. Barguil-Díaz, Ivón Cecilia; Gómez-Mejía, Catherine; Ramírez-González, Julián Andrés; Zapata-Carmona, Sandra Cristina // Medicina UPB;ene-jun2012, Vol. 31 Issue 1, p34 

    Autoimmune diseases are highly prevalent today. These are diseases that sometimes, for their symptoms, can cause mood disturbances in the patient, with depression being one the most common disorders. Hence the importance of recognizing the frequency of depressive disorder occurring in patients...

  • A challenging case of rheumatoid arthritis in an acromegalic patient. Öz&zcedil;akar, Levent; Akinci, Aysen; Bal, Serpil // Rheumatology International;May2003, Vol. 23 Issue 3, p146 

    A 63-year-old man with complaints of joint pain and ankle swelling was evaluated. The arthralgias he described were mainly in the knees, elbows, and shoulders. Accompanying swelling and erythema in his left ankle and left second metacarpophalangeal (MCP) joint had recently ensued. His past...

  • Late-onset systemic lupus erythematosus-associated liver disease. Schiavon, Leonardo; Carvalho-Filho, Roberto; Narciso-Schiavon, Janaína; Lanzoni, Valéria; Ferraz, Maria; Silva, Antonio // Rheumatology International;Sep2012, Vol. 32 Issue 9, p2917 

    Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease, which predominantly affects women under 50 years old. Although liver disease is not included in the diagnostic criteria, abnormal liver tests are common among patients with SLE and, in a significant proportion of those...

  • Rheumatologic manifestations of histoplasmosis: a review. Sizemore, Travis C. // Rheumatology International;Dec2013, Vol. 33 Issue 12, p2963 

    Histoplasmosis is an important cause of morbidity in endemic areas of the USA. Infection is often asymptomatic but can cause a broad spectrum of pathology. Less commonly, histoplasmosis can present with a wide-range of rheumatologic manifestations. The aim of this review is to provide a synopsis...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics