Review: β-blockers are less effective than other antihypertensive drugs for reducing risk for stroke in primary hypertension: COMMENTARY

Rudd, Peter
May 2006
ACP Journal Club;May/Jun2006, Vol. 144 Issue 3, p67
Academic Journal
The article presents comments of the author on a study which found that β-blockers are less effective than other antihypertensive drugs for reducing risk for stroke in primary hypertension. Despite their traditional place in antihypertensive pharmacology, β-blockers have received mixed reviews about net survival benefit, especially when atenolol has been compared with metoprolol, highlighting the possibility of dissimilar, long-term effects from medications of the same drug class. These alterations may accompany the common dominance of peripheral resistance over cardiac output among older hypertensive patients.


Related Articles

  • Nebivolol. Kalus, James S.; Salinitri, Francine D. // Formulary;Nov2004, Vol. 39 Issue 11, p532 

    Discusses the use of the beta-blocker nebivolol for the treatment of hypertension. Pharmacologic properties; Pharmacokinetics; Results of clinical trials; Tolerability; Adverse effects; Drug interactions; Dosing and administration. INSET: Formulary considerations.

  • Hypertension.  // Clinical & Investigative Medicine;Aug97 Supplement, Vol. 20, pS43 

    Presents an abstract of the research manuscript `Evaluation of the anihypertensive and metabolic effects of atenolol and nebivolol in ambulatory hypertensive patients with glucose intolerance,' by L. Poirier, Y. Lacourciere and A. Nadeau. Cardioselective beta blockers.

  • Study diminishes value of beta blockers in treatment of hypertension.  // Formulary;Jan2006, Vol. 41 Issue 1, p40 

    The article examines the efficacy of beta blockers in the treatment of primary hypertension. The Swedish researchers stated that switching hypertension treatment from beta blockers to other low-cost antihypertensive drugs in patients without heart disease have a major health effect without...

  • Heart Rate Variability and Baroreflex Sensitivity during Fosinopril, Irbesartan and Atenolol Therapy in Hypertension. Rabbia, Franco; Silke, Bernard; Carra, Renata; Milan, Alberto; Del Colle, Sara; Pugni, Chiara; Mulatero, Paolo; Chiandussi, Livio; Veglio, Franco // Clinical Drug Investigation;2004, Vol. 24 Issue 11, p651 

    Objective: To evaluate the effects of long-term therapy with fosinopril, irbesartan and atenolol on the autonomic control of the cardiovascular system in hypertensive patients. Methods: We enrolled 58 patients (mean age 38 ± 10 years) with never-treated mild hypertension with no evidence of...

  • atenolol. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p76 

    A definition of the term "atenolol" is presented. It refers to a beta-blocker drug which can be used for the treatment of various diseases, including hypertension, angina pectoris and arrhythmia.

  • Study casts doubt on GP atenolol use.  // Pulse;11/8/2004, Vol. 64 Issue 44, p8 

    Reports on new research on the use of atenolol to by general practitioners to treat hypertensive patients. Doubts on the drug despite its significant blood pressure-lowering effect; Comparison of the effectiveness of the drug with placebo in reducing overall mortality; Incidence of...

  • Microdosing Assessment to Evaluate Pharmacokinetics and Drug Metabolism in Rats Using Liquid Chromatography-Tandem Mass Spectrometry. Jinsong Ni; Hui Ouyang; Mauro Aiello; Carmai Seto; Lisa Borbridge; Takeo Sakuma; Robert Ellis; Devin Welty; Andrew Acheampong // Pharmaceutical Research;Jul2008, Vol. 25 Issue 7, p1572 

    Abstract Purpose  To evaluate the sensitivity requirement for LC-MS/MS as an analytical tool to support human microdosing study with sub-pharmacological dose, investigate proportionality of pharmacokinetics from the microdose to therapeutic human equivalent doses in rats and characterize...

  • Antipressan.  // Royal Society of Medicine: Medicines;2002, p77 

    The article presents information on antipressan, a proprietary, prescription-only preparation of the beta-blocker atenolol. It can be used as an hypertensive for raised blood pressure, as an anti-angina treatment to relieve symptoms and improve exercise tolerance and to regularize heartbeat and...

  • Kalten.  // Royal Society of Medicine: Medicines;2002, p316 

    This article presents information on Kalten from AstraZeneca. It is a proprietary, prescription-only compound preparation of the beta-blocker atenolol and the diuretic drugs hydrochlorothiazide and amiloride hydrochloride. It can be used as an antihypertensive for raised blood pressure, and is...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics