Addition of clopidogrel to aspirin, but not early use of metoprolol, improved overall outcome in acute myocardial infarction: COMMENTARY

Massel, David
May 2006
ACP Journal Club;May/Jun2006, Vol. 144 Issue 3, p59
Academic Journal
The article presents comments of the author on a study regarding the treatment of acute myocardial infarction (AMI). The addition of clopidogrel to aspirin in the setting of ST-segment elevation AMI (STEMI) is modestly effective and safe. Similar magnitudes of benefit were shown in the Clopidogrel in Unstable Angina to Prevent Recurrent Events trial among patients with acute coronary syndromes. A slightly larger effect was seen in the Clopidogrel as Adjunctive Reperfusion Therapy. Routine early IV β-blocker use in STEMI is potentially hazardous and should be avoided.


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