Addition of clopidogrel to aspirin, but not early use of metoprolol, improved overall outcome in acute myocardial infarction

May 2006
ACP Journal Club;May/Jun2006, Vol. 144 Issue 3, p58
Academic Journal
The article discusses a study which finds out whether the addition of clopidogrel to aspirin and the early use of metoprolol improve outcomes in patients hospitalized within 24 hours of suspected acute myocardial infarction (AMI). 45,852 patients hospitalized within 24 hours of onset of symptoms of AMI, having moderate heart failure were eligible for the study. Patients scheduled for primary percutaneous coronary intervention and those with small likelihood of benefit or high risk for adverse effects were excluded. In patients hospitalized within 24 hours of suspected AMI, adding clopidogrel to aspirin and other standard treatments reduced risk for the composite endpoint of death, reinfarction or stroke and did not increase the risk for major bleeding.


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