Ulcerative colitis during CTLA-41g therapy in a patient with rheumatoid arthritis

Amezcua-Guerra, L. M.; Hernández-Martinez, B.; Pineda, C.; Bojalil, R.
July 2006
Gut;Jul2006, Vol. 55 Issue 7, p1059
Academic Journal
The article discusses the case of a 55 year old male with a history of seropositive rheumatoid arthritis refractory to treatment with methotrexate. He was included in the clinical trial of CTLA=4Ig plus MTX clinical trial. Significant clinical and serological responses were achieved during the treatment process. Since CTLA-4Ig has been used to block the interactions between CD80/CD86 on antigen presenting cells and CD28 on T lymphocytes, biological plausibility is possible.


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