TITLE

Gastrointestinal Candida colonisation promotes sensitisation against food antigens by affecting the mucosal barrier in mice

AUTHOR(S)
Yamaguchi, N.; Sugita, R.; Miki, A.; Takemura, N.; Kawabata, J.; Watanabe, J.; Sonoyama, K.
PUB. DATE
July 2006
SOURCE
Gut;Jul2006, Vol. 55 Issue 7, p954
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Backgrounds and aims: Controversy still exists as to whether gastrointestinal colonisation by Candida albicans contributes to aggravation of atopic dermatitis. We hypothesised that Candida colonisation promotes food allergy, which is known to contribute to a pathogenic response in atopic dermatitis. We tested this using a recently established murine Candida colonisation model. Methods: Candida colonisation in the gastrointestinal tract was established by intragastric inoculation with C albicans in mice fed a synthetic diet. To investigate sensitisation against food antigen, mice were intragastrically administered with ovalbumin every other day for nine weeks, and ontiovolbumin antibody titres were measured weekly. To examine gastrointestinal permeation of food antigen, plasma concentrations of ovalbumin were measured following intragastric administration of ovalbumin. Results: Ovalbumin specific IgG and IgE titres were higher in BALB/c mice with Candida colonisation than in normal mice. Gastrointestinal permeation of ovalbumin was enhanced by colonisation in BALB/c mice. Histological examination showed that colonisation promoted infiltration and degranulation of mast cells. Candida colonisation did not enhance ovalbumin permeation in mast cell deficient W/Wv mice but did in congenic littermate control +/+ mice. Reconstitution of mast cells in W/Wv mice by transplantation of bone marrow derived mast cells restored the ability to increase ovalbumin permeation in response to Candida colonisation. Conclusions: These results suggest that gastrointestinal Candida colonisation promotes sensitisation against food antigens, at least portly due to mast cell mediated hyperpermeability in the gastrointestinal mucosa of mice.
ACCESSION #
21399618

 

Related Articles

  • Late-onset atopic eczema and multiple food allergies after infectious mononucleosis. Barnetson, R.St.C.; Hardie, R.A.; Merrett, T.G. // British Medical Journal (Clinical Research Edition);10/24/1981, Vol. 283 Issue 6299, p1086 

    Investigates the case of a patient with late onset atopic eczema and multiple food allergies after infectious monocleosis. Mode of inheritance; Complaints of the patient; Characteristics of the condition.

  • Food allergy in AD: myth vs. reality. Helwick, Caroline // Dermatology Times;Jun2002, Vol. 23 Issue 6, p34 

    Focuses on issues related to food allergies in the U.S. Association of atopic dermatitis in children to food allergy; Percentage of demonstrated food allergy in children; Efficacy of tacrolinus in treating food allergy.

  • Systemic candidiasis: an unusual complication of eating mutton. Bates, J.; Dollery, C.T.; Cohen, J.; Schulenburg, E.; Calam, J.; Winter, Robert // BMJ: British Medical Journal (International Edition);8/26/89, Vol. 298 Issue 6698, p557 

    Examines the complication of systemic candidiasis. Area of the body affected; Signs and symptoms of the disorder; Contribution of the pathogenic Candida albicans for the development of the disease.

  • Clobber your Candida. Meyerowitz, Steve // Better Nutrition;Sep2000, Vol. 62 Issue 9, p34 

    Provides advice for treating and preventing candidiasis in the United States. Characteristics of the microorganism Candida albicans; Role of C. albicans in the distribution of toxic acetaldehydes in the system; Account on the underlying causes of candida infection; Symptoms of candidiasis;...

  • Characterization of Candida Species Isolated from Patients with Vulvovaginitis. Ranjdoust fam, Asghar Salehpour; melli, Manizheh Sayyah; Rahnemaii Akbari, Najibeh Asle; Nokhahi, Iran; Rahnama, Badrosadat // Medical Journal of Tabriz University of Medical Sciences & Healt;Feb/Mar2014, Vol. 35 Issue 6, p70 

    Background and Objectives: Vulvovaginal Candidiasis (VC) is a common mucosal infection in women caused by the opportunistic yeast-like fungus Candida albicans. A significant percentage of these patients (5%) subsequently experience recurrent candida infections. The diagnosis of vulvovaginits is...

  • Conquer Candida Naturally. Lahoz, S. Colet // Alive: Canada's Natural Health & Wellness Magazine;Jan2002, Issue 231, p82 

    Presents information on candidiasis. Predisposing factors for candida overgrowth; Details regarding Candida albicans, the fungus that cause candidiasis in its overgrowth; Treatment of the disease.

  • Beating Candida. Lahoz, S. Colet // Alive: Canada's Natural Health & Wellness Magazine;Mar2003, Issue 245, p102 

    Provides information on candidiasis, a condition caused by the fungus Candida albicans that grows in the gastrointestinal tract and spreads throughout the entire body. Predisposing factors for candida overgrowth; Treatment; Antifungal regimen.

  • Right upper quadrant pain in a diabetic. Smith, Leon G. // Patient Care;7/15/1994, Vol. 28 Issue 12, p154 

    Presents a case study of a man with right upper quadrant pain, with diagnosis of Candida albicans infection. Laboratory findings; Culture of pus cells.

  • EVALUATION OF CANDIDA ALBICANS ALLERGENS REACTIVE WITH SPECIFIC IGE IN ATOPIC DERMATITIS PATIENTS BY IMMUNOBLOTTING. Naseri, Ali; Khosravi, Ali Reza; Moazzeni, Mohammad; Mansouri, Parvin // Jundishapur Journal of Microbiology;2013 Special Edition, p15 

    Introduction and Objectives: Candida albicans, the major etiologic agent of candidiasis, is a normal inhabitant of the alimentary tract and the mucocutaneous regions. It produces important allergenic components which can induce allergic reactions in sensitized patients. Atopic dermatitis is a...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics