TITLE

Multimodal pain stimulations in patients with grade B oesophagitis

AUTHOR(S)
Drewes, A. M.; Reddy, H.; Pedersen, J.; Funch-Jensen, P.; Gregersen, H.; Arendt-Nielsen, I.
PUB. DATE
July 2006
SOURCE
Gut;Jul2006, Vol. 55 Issue 7, p926
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim: To obtain a better understanding of nociceptive processing in patients with oesophagitis. Patients and methods: Eleven patients with grade B oesophagitis were compared with an age and sex matched group of 16 healthy subjects. A probe was positioned in the lower part of the oesophagus. After preconditioning of the tissue, painful mechanical stimuli were applied as distensions with a bag using an impedance planimetric method. Distensions were done before and after pharmacological impairment of distension induced smooth muscle contractions. Thermal stimulation was performed by recirculating water at 1 and 60°C in the bag. The area under the temperature curve (AUC) represented caloric load. The referred pain area (being a proxy for the central pain mechanisms) to the mechanical stimuli was drawn at maximum pain intensities. Results: Patients were hyposensitive to mechanical stimuli, as assessed by the distending volume (F = 8.1, p=0.005). After relaxation of smooth muscle with butylscopolamine, the difference between the two groups was more evident (F=27.4, p<0.001). AUC for cold stimulation was 1048.6 (242.7) °Cxs in controls and 889.8 (202.6) °C2xs in patients (p=0.5). For heat stimuli, AUC values were 323.3 (104.1) and 81.3 (32.3) °Cxs in controls and patients, respectively (p=0.04). The referred pain area to the mechanical stimulations was larger and more widespread in patients (49.3 (6.2) cm² compared with controls 23.9 (7) cm²; p=0.02). Conclusions: The data indicate that peripheral sensitisation of heat sensitive receptors and pathways combined with facilitation of central pain mechanisms may explain the symptoms in patients with oesophagitis.
ACCESSION #
21399612

 

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