Central sensitisation in visceral pain disorders
- Dyspeptic patients with visceral hypersensitivity: sensitisation of pain specific or multimodal pathways? Vandenberghe, J.; Vos, R.; Persoons, P.; Demyttenaere, K.; Janssens, J.; Tack, J. // Gut;Jul2005, Vol. 54 Issue 7, p914
Background and aims: Patients with functional dyspepsia who have hypersensitivity to gastric distension have more prevalent pain, suggesting the presence of hyperalgesia. It is unclear whether this reflects activation of pain specific afferent pathways or multimodal afferent pathways that also...
- Hydrogen Sulphide and Pain. Distrutti, Elenora // Inflammation & Allergy - Drug Targets;Apr2011, Vol. 10 Issue 2, p123
No abstract available.
- Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain. Parenti, Carmela; Marrazzo, Agostino; Aricò, Giuseppina; Cantarella, Giuseppina; Prezzavento, Orazio; Ronsisvalle, Simone; Scoto, Giovanna; Ronsisvalle, Giuseppe // Inflammation;Feb2014, Vol. 37 Issue 1, p261
The compound (âˆ’)-MRV3 [(âˆ’)-methyl (1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)-methyl]-1-phenylcyclopropanecarboxylate] has an assessed antagonist sigma 1 (Ïƒ) profile and showed improved Ïƒ/Ïƒ selectivity with respect to the parent compound (+)-MR200. The Ïƒ receptor is...
- Germs, Gas and the Gut; the Evolving Role of the Enteric Flora in IBS. Quigley, Eamonn M. M. // American Journal of Gastroenterology;Feb2006, Vol. 101 Issue 2, p334
Gas-related symptoms are common in irritable bowel syndrome (IBS), though their pathophysiology remains poorly understood, various studies invoking increased gas production, impaired gas transit, and increased sensitivity to gas. Recent evidence suggests a potential role for bacterial overgrowth...
- Pain management. Sullivan, Beverly A. // Drug Store News;3/15/99, Vol. 21 Issue 5, CHAIN PHARMACY p23
Provides an update on standards of pain management. Discussion on the pathophysiology of pain; Information on the clinical presentation of pain; Assessment of pain.
- Eosinophilic colitis: an update on pathophysiology and treatment. Alfadda, Abdulrahman A.; Storr, Martin A.; Shaffer, Eldon A. // British Medical Bulletin;Dec2011, Vol. 100 Issue 1, p59
Background Primary eosinophilic gastrointestinal disorders, a spectrum of inflammatory conditions, occurs when eosinophils selectively infiltrate the gut in the absence of known causes for such tissue eosinophilia. These may be classified into eosinophilic esophagitis, eosinophilic...
- Opioid pain management: Balancing risks and benefits. Fudin, Jeffrey // Drug Topics;Sep2011, Vol. 155 Issue 9, p46
Pain has a high prevalence in medical practice, yet nearly half of all patients do not receive adequate treatment for pain. Although a wide variety of opioids provide effective pain relief barriers to their use often result in undertreatment, especially for chronkpain. Extended-release products...
- Neurobiology: A pain paradox. Bucci, Mirella // Nature Chemical Biology;Mar2013, Vol. 9 Issue 3, p139
The article focuses on a study which revealed the mechanism of morphine-induced hyperalgesia for development of strategies for treatment of pain through morphine narcotics.
- The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. Parenti, Carmela; Marrazzo, Agostino; Aricò, Giuseppina; Parenti, Rosalba; Pasquinucci, Lorella; Ronsisvalle, Simone; Ronsisvalle, Giuseppe; Scoto, Giovanna // Inflammation Research;Mar2014, Vol. 63 Issue 3, p231
Objective and design: The sigma 1 (Ïƒ) receptor, which is widely distributed in the CNS in areas that are known to be important for pain control, may play a role in persistent pain characterized by the hypersensitivity of nociceptive transmission. Here, we investigated the effect of Ïƒ...