TITLE

Determination of volatile residual solvents in pharmaceutical products by headspace liquid-phase microextraction gas chromatography-flame ionization detector

AUTHOR(S)
Xia Wang; Ting Jiang; Jinpeng Yuan; Chuange Cheng; Jianhua Liu; Junbo Shi; Rusong Zhao
PUB. DATE
August 2006
SOURCE
Analytical & Bioanalytical Chemistry;Aug2006, Vol. 385 Issue 6, p1082
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This paper demonstrates headspace liquid-phase microextraction (HS-LPME) as used for the determination of volatile residual solvents in pharmaceutical products. This method is based on headspace liquid-phase microextraction capillary column gas chromatography. Under optimum conditions, the linerary of the method ranged from 1 to 1,000 mg l−1. The limits of detection are 0.2–2.0 mg l−1 and relative standard deviations (RSD) for most of the volatile solvents were below 10%. This novel method is applied to the analysis of volatile residual solvents in pharmaceutical products with satisfactory results.
ACCESSION #
21396815

 

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