Microwave-assisted regioselective synthesis of acyclic nucleosides through an alkylating reaction with 2-oxa-1,4-butanediol diacetate

Guirong Qu; Suhui Han; Zhiguang Zhang; Mingwei Geng; Feng Xue
May 2006
Canadian Journal of Chemistry;May2006, Vol. 84 Issue 5, p819
Academic Journal
An efficient and green procedure for the synthesis of purine acyclic nucleosides through microwave-assisted alkylation of various purine nucleobases with 2-oxa-1,4-butanediol diacetate in the absence of solvent and catalyst is described. The advantages of using this method include its environmental friendliness, simple manipulation, short reaction time, high regioselectivity, and good yields.


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