TITLE

Microwave-assisted regioselective synthesis of acyclic nucleosides through an alkylating reaction with 2-oxa-1,4-butanediol diacetate

AUTHOR(S)
Guirong Qu; Suhui Han; Zhiguang Zhang; Mingwei Geng; Feng Xue
PUB. DATE
May 2006
SOURCE
Canadian Journal of Chemistry;May2006, Vol. 84 Issue 5, p819
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An efficient and green procedure for the synthesis of purine acyclic nucleosides through microwave-assisted alkylation of various purine nucleobases with 2-oxa-1,4-butanediol diacetate in the absence of solvent and catalyst is described. The advantages of using this method include its environmental friendliness, simple manipulation, short reaction time, high regioselectivity, and good yields.
ACCESSION #
21197126

 

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