TITLE

Synthesis of mono- and di-sialophospholipids via the H-phosphonate approach

AUTHOR(S)
Hongbin Yan; Jennings, Harold J.
PUB. DATE
April 2006
SOURCE
Canadian Journal of Chemistry;Apr2006, Vol. 84 Issue 4, p540
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To overcome their inherent instability, stable modified mono- and di-sialophospholipids of the group C meningococcal polysaccharide were synthesized. Stability was achieved by introducing a spacer between the sialic acid residue and the phospholipid component, and by replacing the native ester linkages to the lipid by ether linkages. Mono- and di-hydroxylethylenesialosides were coupled to phosphoglyceroldietherlipid using H-phosphonate chemistry to give the anomerically pure sialophospholipids in good yields.
ACCESSION #
21197111

 

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