Group A Streptococcal Myonecrosis: Increased Vimentin Expression after Skeletal-Muscle Injury Mediates the Binding of Streptococcus pyogenes

Bryant, Amy E.; Bayer, Clifford R.; Huntington, Jeremy D.; Stevens, Dennis L.
June 2006
Journal of Infectious Diseases;6/15/2006, Vol. 193 Issue 12, p1685
Academic Journal
Necrotizing fasciitis and myonecrosis caused by invasive infection with group A streptococci (GAS) are life-threatening conditions that have reemerged worldwide. Half of all GAS myonecrosis cases have no known portal of entry; yet, for unknown reasons, infection becomes established precisely at the site of a prior, nonpenetrating minor injury, such as a muscle strain. We hypothesized that GAS establishes infection by binding to surface molecules that are up-regulated on injured skeletal-muscle cells. Here, we isolated and identified vimentin as the major skeletal-muscle GAS-binding protein. Furthermore, we found that vimentin expression was up-regulated on injured skeletal-muscle cells in vitro and was expressed in muscle tissues from a patient with GAS myonecrosis who died of streptococcal toxic shock syndrome. These findings provide a molecular mechanism to explain the development of severe GAS soft-tissue infections at the sites of prior minor muscle trauma. This understanding may provide a basis for novel preventive strategies or therapies for patients with this devastating infection.


Related Articles

  • Growth factor-enriched autologous plasma improves wound healing after surgical debridement in odontogenic necrotizing fasciitis: a case report.  // Journal of Medical Case Reports;2011, Vol. 5 Issue 1, p1 

    The article presents a case study of a 69 year old Mexican male who was suffering from Cervical necrotizing fasciitis (CNF), a fulminant infection of odontogenic origin. It mentions that surgical debridement and the administration of antibiotics can be used for the treatment of CNF. It also...

  • Necrotizing fasciitis--the hazards of delay. Burge, Timothy Stuart // Journal of the Royal Society of Medicine;Jun1995, Vol. 88 Issue 6, p342P 

    Necrotizing fasciitis was first described in a specific body region by Fournier in 18831 and as a more generalized condition by Meleney in 1924. The use of the term 'necrotizing fasciitis' can be attributed to Wilson in 1952. It is perceived as a rare condition, causing potentially devastating...

  • 3 Smart Things About.  // Wired;Oct2013, Vol. 21 Issue 10, p92 

    The article presents three facts about flesh-eating bacteria.

  • Epidemiology of Invasive Group A Streptococcus Disease in the United States, 1995-1999. O'Brien, Katherine L.; Beall, Bernard; Barrett, Nancy L.; Cieslak, Paul R.; Reingold, Arthur; Farley, Monica M.; Danila, Richard; Zell, Elizabeth R.; Facklam, Richard; Schwartz, Benjamin; Schuchat, Anne // Clinical Infectious Diseases;8/1/2002, Vol. 35 Issue 3, p268 

    Severe invasive group A streptococcal (GAS) disease is believed to have reemerged during the past 10-20 years. We conducted active, laboratory, population-based surveillance in 5 US states (total population, 13,214,992). From 1 July 1995 through 31 December 1999, we identified 2002 episodes of...

  • Necrotising fasciitis complicating varicella. De Benedictis, F. M.; Osimani, P. // Archives of Disease in Childhood;Jul2008, Vol. 93 Issue 7, p619 

    The article reports on the diagnosis of Group A beta-haemolytic Streptococcus (GABHS) particularly necrotising fasciitis on a 2-year-old girl after suffering from varicella. It is diagnosed on a two-year-old girl who was admitted in a hospital for fever and complained of pain and swelling in the...

  • Community-Acquired Necrotizing Fasciitis Caused by Serratia marcescens: Case Report and Review. Liangpunsakul, S.; Pursell, K. J. // European Journal of Clinical Microbiology & Infectious Diseases;Jul2001, Vol. 20 Issue 7, p509 

    The article focuses on community-acquired necrotizing fasciitis, which is caused by serratia marcescens. Serratia marcescens is a gram-negative bacillus that been has recognized as a human pathogen since the 1960s.This organism is known to cause a variety of infections including bacteremia,...

  • Molecular Epidemiologic Comparison of 2 Unusual Clusters of Group A Streptococcal Necrotizing Fasciitis in Hawaii. Erdem, Guliz; Ford, Jacqueline M.; Kanenaka, Rebecca Y.; Abe, Lucienne; Yamaga, Karen; Effler, Paul V. // Clinical Infectious Diseases;6/15/2005, Vol. 40 Issue 12, p1851 

    Two clusters of necrotizing fasciitis (NF) due to group A streptococcus (GAS) were identified on the Hawaiian islands of Kauai and Maui during 1997 and 2002, respectively. The emm gene sequence types and the pulsed-field gel electro- phoresis patterns were determined for 6 isolates recovered...

  • Necrotizing fasciitis in neonates. Nazir, Zafar // Pediatric Surgery International;Aug2005, Vol. 21 Issue 8, p641 

    Necrotizing fasciitis (NF) is a potentially life-threatening infection of soft tissues. It is characterized by rapid spread of inflammation and infection with widespread necrosis of fascia, subcutaneous tissues, and overlying skin. NF is usually reported in adults with preexisting medical...

  • Successful Treatment of Three Consecutive Necrotizing Fasciitis Cases in Rural Eastern North Carolina: Rising Incidence Means More Wounds. Slayton, Stephanie A. // Acute Care Perspectives;Summer2008, Vol. 17 Issue 2, p6 

    The article offers information on the successful treatment of three cases of necrotizing fasciitis (NF) in Eastern North Carolina. It states that NF, known as the flesh-eating bacteria, is a life threatening diseases that has increased in incidences in previous years. The National Institute of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics