TITLE

Airflow Decline after Myeloablative Allogeneic Hematopoietic Cell Transplantation: The Role of Community Respiratory Viruses

AUTHOR(S)
Erard, Veronique; Chien, Jason W.; Kim, Hyung W.; Nichols, W. Garrett; Flowers, Mary E.; Martin, Paul J.; Corey, Lawrence; Boeckh, Michael
PUB. DATE
June 2006
SOURCE
Journal of Infectious Diseases;6/15/2006, Vol. 193 Issue 12, p1619
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We conducted a 12-year retrospective study to determine the effects that the community respiratory-virus species and the localization of respiratory-tract virus infection have on severe airflow decline, a serious and fatal complication occurring after hematopoietic cell transplantation (HCT). Of 132 HCT recipients with respiratory-tract virus infection during the initial 100 days after HCT, 50 (38%) developed airflow decline ≤1 year after HCT. Lower-respiratory-tract infection with parainfluenza (odds ratio [OR], 17.9 [95% confidence interval {CI}, 2.0-160]; P = .01) and respiratory syncytial virus (OR, 3.6 [95% CI, 1.0-13]; P = .05) independently increased the risk of development of airflow decline ≤1 year after HCT. The airflow decline was immediately detectable after infection and was strongest for lower-respiratory-tract infection with parainfluenza virus; it stabilized during the months after the respiratory-tract virus infection, but, at ≤1 year after HCT, the initial lung function was not restored. Thus, community respiratory virus-associated airflow decline seems to be specific to viral species and infection localization.
ACCESSION #
21175361

 

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