An 18-year-old male with hematuria, renal insufficiency, and defective synthesis of type IV collagen

Markowitz, G. S.; Gelber, C.; D'Agati, V. D.
June 2006
Kidney International;Jun2006, Vol. 69 Issue 12, p2278
Academic Journal
The article presents a case report on an 18-year old patient who was diagnosed to have hereditary nephritis or commonly called alport syndrome. The patient, who was found to have a 2-3 week history of headaches, edema and fatigue, was subjected to laboratory and nephrologic evaluation. After which, renal biopsy was performed. Ultrastructural evaluation showed diagnostic findings of hereditary nephritis (HN) with glomerular basement membranes (GBM) thickening and lamellation. The main clinical manifestation of HN during childhood and adolescence is hematuria, which later on can develop to proteinuria and subsequently followed by renal failure and end-stage renal disease.


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