Predictors of Axillary Lymph Node Metastasis in T1 Breast Carcinoma

Shoup, Margo; Malinzak, Lauren
August 1999
American Surgeon;Aug1999, Vol. 65 Issue 8, p748
Academic Journal
This study was designed to determine the predictors of axillary lymph node metastasis in T1a (0.5 cm and ≤1.0 cm), and T1c (>1.0 cm and ≤2.0 cm) breast cancers. The charts of 204 patients who underwent axillary lymph node dissections for T[sub 1] breast carcinomas at our institution were reviewed. Of these, 23 (11%) patients had T1a cancers, 55 (27%) patients had T1b cancers, and 126 (62%) patients were diagnosed with T1c lesions. Fifty patients (24.5%) had axillary node metastases. Of those with T1a lesions, one (4.3%) patient had axillary node involvement, compared with 9 (16.4%) patients with T1b and 40 (31.7%) patients with T1c lesions. Nodal involvement was significantly increased in T1c cancer compared with either T1a (odds ratio = 8.24; P < 0.05) or T1b (odds ratio = 2.73; P < 0.05). Similar results were found in tumors with grade 3 nuclear pleomorphism (odds ratio = 10.45 versus grade 1 and 3.46 versus grade 2; P < 0.05). The presence of lymphovascular invasion was also associated with an increased likelihood of nodal involvement (odds ratio = 3.15; P < 0.05). Predictors of axillary lymph node metastasis in T[sub 1] breast carcinomas include increasing tumor size, grade 3 nuclear pleomorphism, and the presence of lymphovascular invasion. These predictors may have a role in stratifying patients with T[sub 1] breast carcinomas into subgroups that may benefit from less invasive methods of evaluating axillary lymph node status.


Related Articles

  • EVALUATION OF PLANAR SCINTIMAMMOGRAPHY WITH [sup99M]Tc-MIBI IN THE DETECTION OF AXILLARY LYMPH NODE METASTASES OF BREAST CARCINOMA. Danielsson, R.; Bone, B.; Perbeck, L.; Aspelin, P. // Acta Radiologica;Sep1999, Vol. 40 Issue 5, p491 

    Evaluates the role of planar scintimammography with [sup 99m]Tc-MIBI in the detecting axillary lymph node metastases of breast carcinoma. Status of lymph nodes verified with histopathology; Detection of axillary lymph nodes involvement; Prognostic factors for survival of patients.

  • The effect of sentinel lymph node biopsy on the Nottingham Prognostic Index in breast cancer patients. Cserni, G. // Journal of the Royal College of Surgeons of Edinburgh;Aug2001, Vol. 46 Issue 4, p1 

    The Nottingham Prognostic Index (NPI) is a prognostic variable suitable for the stratification of breast cancer patients for adjuvant systemic treatment. The impact of sentinel node biopsy (SNB) and of the assessment of nodal involvement was evaluated in 136 successful SNB procedures completed...

  • The hidden sentinel node in breast cancer. Tanis, J.; van Sandick, W.; Nieweg, E.; Valdés Olmos, A.; Rutgers, T.; Hoefnagel, A.; Kroon, R. // European Journal of Nuclear Medicine & Molecular Imaging;2002, Vol. 29 Issue 3, p305 

    The purpose of this study was to analyse the occurrence of non-visualisation during preoperative lymphoscintigraphy for sentinel node identification in breast cancer. Preoperative lymphoscintigraphy was performed in 495 clinically node-negative breast cancer patients (501 sentinel node...

  • Complete sectioning of axillary sentinel nodes in patients with breast cancer. Analysis of two different step sectioning and immunohistochemistry protocols in 246 patients. Cserni, G. // Journal of Clinical Pathology;Dec2002, Vol. 55 Issue 12, p926 

    Aims: To evaluate two detailed step sectioning protocols for sentinel lymph nodes (SLNs). Methods: After vital dye or combined dye and radiocolloid guided biopsy, SLNs were fixed in formalin and embedded in paraffin wax. In protocol A, SLNs from 123 patients were sectioned in steps of 50-100...

  • Physical Examination: The First Step in Sophisticated Diagnostic Path of Breast Cancer. Darko, Zdravkovic; Miroslav, Granic; Marija, Zdravkovic; Tomislav, Randjelovic; Dejan, Nikolic; Nebojsa, Ivanovic // World Journal of Surgery;Sep2013, Vol. 37 Issue 9, p2252 

    A letter to the editor is presented in response to the article "Clinical assessment of axillary lymph nodes and tumor size in breast cancer compared with histopathological examination: A population-based analysis of 2, 537 women," by S. Majid and colleagues in the 2013 issue.

  • MIRROR: Sentinel node status linked to axillary recurrence in breast cancer.  // Hem/Onc Today;7/25/2009, Vol. 10 Issue 14, p12 

    The article discusses a study on the association between sentinel lymph node status and axillary recurrence in breast cancer patients.

  • Risk for axillary lymph node involvement in early breast cancer changed at age 70.  // Hem/Onc Today;6/25/2009, Vol. 10 Issue 12, p27 

    The article discusses research being done on breast cancer and axillary lymph node involvement, referencing a study by J. Wildiers et al, published in a 2009 issue of the "Journal of Clinical Oncology."

  • MANAGEMENT OF REGIONAL NODES IN BREAST CANCER. Bundred, N.J.; Morgan, D.A.L.; Dixon, J.M. // BMJ: British Medical Journal (International Edition);11/5/94, Vol. 309 Issue 6963, p1222 

    Examines the management of regional nodes in breast cancer. Importance of lymph drainage from the breast; Methods for the control of lymphoedema; Recommendations for the management of auxiliary nodes in patients with operable invasive breast cancer.

  • The Feasibility and Accuracy of the Sentinel Lymph Node Biopsy for Breast Carcinoma. Jaderborg, Jana M; Harrison, Paul B. // American Surgeon;Aug1999, Vol. 65 Issue 8, p699 

    As the procedure of sentinel lymph node biopsy for breast cancer becomes more widely available, the practicality of it in the hands of general surgeons should be assessed. This is a study of the accuracy and use of this procedure. A prospective study was conducted at two university-affiliated...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics