TITLE

Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea

AUTHOR(S)
Heinzer, R. C.; Stanchina, M. L.; Malhotra, A.; Jordan, A. S.; Patel, S. R.; Lo, Y.-L.; Wellman, A.; Schory, K.; Dover, L.; White, D. P.
PUB. DATE
May 2006
SOURCE
Thorax;May2006, Vol. 61 Issue 5, p435
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background: Previous studies have shown that changes in lung volume influence upper airway size and resistance, particularly in patients with obstructive sleep apnoea (OSA), and that continuous positive airway pressure (CPAP) requirements decrease when the lung volume is increased. We sought to determine the effect of a constant lung volume increase on sleep disordered breathing during non-REM sleep.Methods: Twelve subjects with OSA were studied during non-REM sleep in a rigid head-out shell equipped with a positive/negative pressure attachment for manipulation of extrathoracic pressure. The increase in lung volume due to CPAP (at a therapeutic level) was determined with four magnetometer coils placed on the chest wall and abdomen. CPAP was then stopped and the subjects were studied for 1 hour in three conditions (in random order): (1) no treatment (baseline); (2) at "CPAP lung volume", with the increased lung volume being reproduced by negative extrathoracic pressure alone (lung volume 1, LV1); and (3) 500 ml above the CPAP lung volume(lung volume 2, LV2).Results: The mean (SE) apnoea/hypopnoea index (AHI) for baseline, LV1, and LV2, respectively, was 62.3 (10.2), 37.2 (5.0), and 31.2 (6.7) events per hour (p = 0.009); the 3% oxygen desaturation index was 43.0 (10.1), 16.1 (5.4), and 12.3 (5.3) events per hour (p = 0.002); and the mean oxygen saturation was 95.4 (0.3)%, 96.0 (0.2)%, 96.3 (0.3)%, respectively (p = 0.001).Conclusion: An increase in lung volume causes a substantial decrease in sleep disordered breathing in patients with OSA during non-REM sleep.
ACCESSION #
21039844

 

Related Articles

  • First night effect for polysomnographic data in children and adolescents with suspected sleep disordered breathing. Verhulst, S. L.; Schrauwen, N.; De Backer, W. A.; Desager, K. N. // Archives of Disease in Childhood;Mar2006, Vol. 91 Issue 3, p233 

    Aims: To assess the presence of a first night effect (FNE) in children and adolescents and to examine if a single night polysomnography (PSG) is sufficient for diagnosing obstructive sleep apnoea syndrome (OSAS). Methods: Prospective case study of 70 patients (group 1: 2–6 years, n = 22;...

  • Editorial [Hot Topic:Sleep Medicine (Guest Editor: Salim Surani)]. Surani, Salim // Current Respiratory Medicine Reviews;2007, Vol. 3 Issue 4, p240 

    For the last 20 years sleep medicine has been recognized as a separate clinical specialty. Pulmonary physicians first became involved in the arena of sleep medicine as obstructive sleep apnea and sleep related breathing disorders were recognized. Although sleep-disordered breathing had been...

  • The effects of gender and age on REM-related sleep-disordered breathing. Brian Koo; Jesse Dostal; Octavian Ioachimescu; Kumaraswamy Budur // Sleep & Breathing;Aug2008, Vol. 12 Issue 3, p259 

    Abstract  Sleep disordered breathing occurring predominantly in rapid eye movement REM sleep (rapid-eye-movement-related sleep-disordered breathing, REM SDB) is present in 10 to 36% of patients undergoing polysomnography (PSG) for suspected obstructive sleep apnea (O’Connor et al....

  • Freie Vorträge Block 7: Schlafmedizin--aktuelle Trends.  // Somnologie;Feb2003 Supplement, Vol. 7, p59 

    This article discusses a number of studies on sleep disorders. The studies cover rapid eye movement sleep, sleep disorders in neurosurgical diseases, and obstructive sleep apnea syndrome. The methods used in the studies are given. Moreover, the article examines the effectiveness of drugs for...

  • Sleep disorders linked to children with migraine?  // Contemporary Pediatrics;May2008, Vol. 25 Issue 5, p17 

    The article focuses on a study which examined the link between migraine and sleep disorders in children in the U.S. The study included 90 children who were diagnosed with migraine, chronic or tension headache and sleep problems. It discovered that 56 percent of children with migraine had sleep...

  • Anatomic Abnormalities and OBESITY. JACOBOWITZ, OFER // Sleep Review;Mar2009, Vol. 10 Issue 2, p26 

    The article explains a case study wherein a 33-year-old obese male patient was treated for obstructive sleep apnea (OSA) by performing partial midline Coblation glossectomy and inferior turbinate reduction to improve airway structure and function. The entry notes that surgeons use Coblation...

  • El síndrome de apnea obstructiva del sueño y su importancia en la medicina perioperatoria. Covarrubias-Gómez, Alfredo; Guevara-López, Uriah; Haro-Valencia, Reyes; Alvarado-Suárez, Mariela // Revista Medica del IMSS;jul/ago2007, Vol. 45 Issue 4, p371 

    Obstructive sleep apnea (OSA) is a common sleep-related disorder among the general population. This disorder occurs in all sleep stages, although is more intense during the REM sleep (rapid eye movement). In this stage appears generalized muscle atony, which includes the hypopharyngeal muscles;...

  • The Snoring Sickness.  // Time;12/27/1976, Vol. 108 Issue 26, p65 

    The article discusses the nature and characteristics of sleep apnea, which has been a common disorder in the U.S. It cites the case of English teacher Norman Siegel from Bridgeport, Connecticut, who still suffered the disorder despite his series of medical examinations. However, a group of sleep...

  • Effects of the Full Breath Solution Appliance for the Treatment of Obstructive Sleep Apnea: A Preliminary Study. Singh, G. Dave; Keropian, Bryan; Pillar, Giora // CRANIO: The Journal of Craniomandibular & Sleep Practice;Apr2009, Vol. 27 Issue 2, p109 

    The aim of this study is to determine the effects of the Full Breath Solution (FBS) appliance in the management of obstructive sleep apnea (OSA) in 21 adults diagnosed with OSA. Oxygen saturation (SaO2) and apnea-hypopnea index (AHI) readings taken from polysomnographs (PSGs) indicated that the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics