Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function

Young, R. P.; Hopkins, R.; Black, P. N.; Eddy, C.; Wu, L.; Gamble, G. D.; Mills, G. D.; Garrettt, J. E.; Eaton, T. E.; Rees, M. I.
May 2006
Thorax;May2006, Vol. 61 Issue 5, p394
Academic Journal
Background: Chronic obstructive pulmonary disease (COPD) is predominantly the consequence of chronic smoking exposure, but its development may be influenced by genetic variants that affect lung remodelling, inflammation, and defence from oxidant stress. A study was undertaken to determine whether genetic variants within genes encoding the antioxidant enzymes superoxide dismutase (SOD) and catalase may be associated with the development of impaired lung function. Methods: In a case-control study, the allele and genotype frequencies of functional polymorphisms from SOD1 (CuZnSOD), SOD2 (MnSOD), SOD3 (extracellular SOD), and catalase (CAT) were compared in chronic smokers with normal lung function (resistant smokers) and in those with COPD. Results: Significantly higher frequencies of the G allele and CG/GG genotype of the 213 SOD3 polymorphism were found in resistant smokers (odds ratios (ORs) 4.3 (95% CI 1.5 to 13.3) and 4.2, 95% Cl 1.4 to 13.3), Bonferroni corrected p=0.02 and p=0.02, respectively) than in those with COPD. There were no differences between the COPD and resistant smokers for the SOD1, SOD2, or CAT polymorphisms tested. Conclusions: The 21 3Gly variant of the SOD3 gene may, through antioxidant or anti-inflammatory effects, confer a degree of resistance in some smokers to the development of COPD.


Related Articles

  • A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. R P Young // Postgraduate Medical Journal;Oct2009, Vol. 85 Issue 1008, p515 

    BACKGROUND: Epidemiological and family studies suggest that lung cancer results from the combined effects of age, smoking and genetic factors. Chronic obstructive pulmonary disease (COPD) is also an independent risk factor for lung cancer and coexists in 40–60% of lung cancer cases....

  • Decline in FEV1 related to genetic polymorphisms (+138insA/delA and Lys198Asn) of the endothelin-1 gene in COPD. A pilot study. KAPARIANOS, A.; ARGYROPOULOU, E.; EFREMIDIS, G.; FLORDELLIS, C.; SPIROPOULOS, K. // European Review for Medical & Pharmacological Sciences;2010, Vol. 14 Issue 10, p705 

    Background: Endothelin-1 (ET-1) is a potent vasoconstrictor and bronchoconstrictor but it has been shown to have also proinflammatory properties. Its ability to attract inflammatory cells in its site of production, upregulates the synthesis of adhesion molecules and stimulates the release of...

  • Ageing, smoking and oxidative stress. Donohue, J. F. // Thorax;Jun2006, Vol. 61 Issue 6, p461 

    The article discusses that chronic obstructive pulmonary disease (COPD) is the fifth leading cause of death worldwide. Continued exposure to tobacco promotes a more rapid decline in lung function, and if exposure is stopped, the disease may still progress to aging and persistent inflammation....

  • Antioxidant Supplementation Prevents Oxidation and Inflammatory Responses Induced by Sidestream Cigarette Smoke in Old Mice. Zhang, Jin; Jiang, Shuguang; Watson, Ronald R. // Environmental Health Perspectives;Oct2001, Vol. 109 Issue 10, p1007 

    Sidestream cigarette smoke (SSCS) makes up about 85% of significantly toxic environmental tobacco smoke (ETS). Reactive oxygen species (ROS) in SSCS play an important role in the pathogenesis of a wide range of diseases. Interleukin-6 is a pro-inflammatory cytokine and is closely linked with...

  • Does vitamin E supplementation help in COPD? Jindal, S. K. // Indian Journal of Medical Research;Dec2008, Vol. 128 Issue 6, p686 

    The author focuses on whether vitamin E supplementation helps in the prevention and management of chronic obstructive pulmonary disease (COPD). The author provides information on the results of a study from India wherein the authors report an augmentation of antioxidant defenses but no clinical...

  • Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease. Hackett, Tillie L.; Scarci, Marco; Lu Zheng; Wan Tan; Treasure, Tom; Warner, Jane A. // Respiratory Research;2010, Vol. 11, p180 

    Background: There is accumulating evidence that oxidative stress plays an important role in the pathophysiology of chronic obstructive pulmonary disease (COPD). One current hypothesis is that the increased oxidant burden in these patients is not adequately counterbalanced by the lung antioxidant...

  • Smoking status and tumour necrosis factor-alpha mediated systemic inflammation in COPD patients. Tanni, Suzana E.; Pelegrino, Nilva R. G.; Angeleli, Aparecida Y. O.; Correa, Camila; Godoy, Irma // Journal of Inflammation;2010, Vol. 7, p29 

    Background: Smoking cause airway and systemic inflammation and COPD patients present low grade inflammation in peripheral blood. However, data on the influence of smoking itself on systemic inflammation in COPD patients are scarce. This study investigated the association between inflammation,...

  • Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD. Arunachalam, Gnanapragasam; Sundar, Isaac K.; Jae-woong Hwang; Hongwei Yao; Rahman, Irfan // Journal of Inflammation;2010, Vol. 7, p34 

    Background: Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The...

  • Lung density on high resolution computer tomography (HRCT) reflects degree of inflammation in smokers. Karimi, Reza; Tornling, Göran; Forsslund, Helena; Mikko, Mikael; Wheelock, Åsa M.; Nyrén, Sven; Sköld, Carl Magnus // Respiratory Research;2014, Vol. 15 Issue 2, p1 

    Background: Smokers have increased cell concentration in the lower respiratory tract indicating a chronic inflammatory state, which in some individuals may lead to development of chronic obstructive pulmonary disease (COPD). Computer tomography (CT) imaging provides means of quantifying...


Read the Article


Sign out of this library

Other Topics