TITLE

On-column sample enrichment for the high-sensitivity sheath-flow CE-MS analysis of peptides

AUTHOR(S)
Sandra, K.; Lynen, F.; Devreese, B.; Van Beeumen, J.; Sandra, P.
PUB. DATE
July 2006
SOURCE
Analytical & Bioanalytical Chemistry;Jul2006, Vol. 385 Issue 4, p671
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A sample enrichment technique to increase sensitivity in capillary electrophoresis–mass spectrometry (CE-MS) is described. Peptides or glycopeptides are retained and concentrated on a short (3–5-mm) reversed-phase (C18) packed-bed situated in the fused-silica separation capillary and are subsequently released for electrophoretic separation by injection of an organic elutant. The concentration limits of detection are in the high picomolar range with a sheath-flow CE-MS interface.
ACCESSION #
21029096

 

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