TITLE

Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia

AUTHOR(S)
Benders, M. J. N. L.; Bos, A. F.; Rodemaker, C. M. A.; Rijken, M.; Torrance, H. L.; Groenendaal, F.; van Bel, F.
PUB. DATE
May 2006
SOURCE
Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2006, Vol. 91 Issue 3, pF163
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To investigate whether postnatal allopurinol would reduce free radical induced reperfusion/ reoxygenation injury of the brain in severely asphyxiated neonates. Method: In an interim analysis of a randomised, double blind, placebo controlled study, 32 severely asphyxiated infants were given allopurinol or a vehicle within four hours of birth. Results: The analysis showed an unaltered (high) mortality and morbidity in the infants treated with allopurinol. Conclusion: Allopurinol treatment started postnatally was too late to reduce the early reperfusion induced free radical surge. Allopurinol administration to the fetus with (imminent) hypoxia via the mother during labour may be more effective in reducing free radical induced post-asphyxial brain damage.
ACCESSION #
20826068

 

Related Articles

  • Fatal asphyxial episodes in the very young: classification and diagnostic issues. Roger Byard; Lisbeth Jensen // Forensic Science, Medicine & Pathology;Sep2007, Vol. 3 Issue 3, p177 

    Abstract  Infants and young children are exposed to a relatively limited range of circumstances that may result in accidental or inflicted asphyxial deaths. These usually involve situations that interfere with oxygen uptake by the blood, or that decrease the amount of circulating oxygen....

  • Ingested and aspirated foreign bodies: Making sure that what went in comes out. Arnold, Linda D. // Contemporary Pediatrics;Nov2006, Vol. 23 Issue 11, p32 

    The article provides information on diagnosing and treating foreign-body ingestion and aspiration in children. In the U.S., 92,166 cases of foreign-body ingestion and aspiration were reported to poison centers in 2003 and ninety-one percent of the calls involved children, most younger than 6...

  • Effect of sustained inflation duration; resuscitation of near-term asphyxiated lambs. Klingenberg, Claus; Sobotka, Kristina S.; Ong, Tracey; Allison, Beth J.; Schmölzer, Georg M.; Moss, Timothy J. M.; Polglase, Graeme R.; Dawson, Jennifer A.; Davis, Peter G.; Hooper, Stuart B. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2013, Vol. 98 Issue 3, pF222 

    Objective The 2010 ILCOR neonatal resuscitation guidelines do not specify appropriate inflation times for the initial lung inflations in apnoeic newborn infants. The authors compared three ventilation strategies immediately after delivery in asphyxiated newborn lambs. Design Experimental animal...

  • INHALED FOREIGN BODIES. Williams, Helen // Archives of Disease in Childhood -- Education & Practice Edition;Aug2005, Vol. 90 Issue 2, pep31 

    Describes several cases of inhaled foreign bodies in children. Details of the chest x-ray of a 9 year-old-boy who had bitten on a Lego toy; Manifestations in a 20-month old boy who had a witnessed choking episode while eating a pistachio nut; Information on the case of an 8-year-old boy who...

  • A Child with Traumatic Asphyxia. Muthukrishnan, Lakshmi; Raman, Radhika // Indian Journal of Emergency Pediatrics;Jan-Mar2013, Vol. 5 Issue 1, p13 

    Background: Most reports of traumatic asphyxia, a condition which is rare in children pertain to injuries sustained following motor vehicle accidents. The clinical picture which is diagnostic of this condition should be recognized for appropriate management. Objective: We report a child with...

  • Drowning and Near-Drowning Involving Children: A Five Year Total Population Study from the City and County of Honolulu. Pearn, John H.; Wong, Richard Y. K.; Brown III, Joseph; Yi-Chuan Ching; Bart Jr., Robert; Hammar, Sherrel // American Journal of Public Health;May79, Vol. 69 Issue 5, p450 

    Abstract: A study of all serious childhood immersion accidents (both drowned and near-drowned cases) is reported from Hawaii. This is a total population-based survey of 140 consecutive cases (0-15 years) occurring during the five-year period 1973-1977. Age-specific, sex-specific, and...

  • A 5-day-old with rapid breathing: Breaking new ground. Gianvecchio, Christopher; Tarrago, Sonja; Tunnessen, Jr., Walter W. // Contemporary Pediatrics;Aug2001, Vol. 18 Issue 8, p29 

    Presents the medical of a five-day-old infant with rapid breathing. Medical history of the mother; Tests conducted on the infant; Result of radiographs; Possible diagnosis.

  • Can a cat smother and kill a baby? Kearney, Michael S.; Dahl, Lauritz B.; Stalsberg, Helge // British Medical Journal (Clinical Research Edition);9/18/1982, Vol. 285 Issue 6344, p777 

    Presents a case report on infant death due to asphyxia secondary to cat smothering. Complications observed after the incident; Detection of brain defects postmortem; Evidence of brain lesions typical from severe hypoxemia.

  • Morbilidad en neonatos a término relacionada con la vía de nacimiento. Becerra, Aída Delgado; Del Rosario Ortiz Almeralla, María; Carrocera, Luis A. Fernández; Cabrales, Leyla María Arroyo // Ginecologia y Obstetricia de Mexico;ago2007, Vol. 75 Issue 8, p471 

    Background: Injuries associated to tract of birth and breathing disease constitutes a risk for life and function in the perinatal period, with an incidence referred in national literature that varies from 2-7% for the first one to 12.4% in the international literature for second. Objective: To...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics