Association between the Replication Capacity and Mother-to-Child Transmission of HIV-1, in Antiretroviral Drug -- Naive Malawian Women

Eshleman, Susan H.; Lie, Yolanda; Hoover, Donald R.; Shu Chen; Hudelson, Sarah E.; Fiscus, Susan A.; Petropoulos, Christos J.; Kumwenda, Newton; Parkin, Neil; Taha, Taha E.
June 2006
Journal of Infectious Diseases;6/1/2006, Vol. 193 Issue 11, p1512
Academic Journal
Replication capacity and transmission of human immunodeficiency virus (HIV)-1 in antiretroviral drug-naive Malawian women who had subtype C infection were investigated. Infant children of these women received either 1 dose of nevirapine or 1 dose of nevirapine plus 1 week of daily doses of zidovudine. PhenoSense HIV was used to determine replication capacity in 49 women whose infants were infected with HIV-1 and in 47 women whose infants were uninfected by 6-8 weeks of age. Mean replication capacity was higher in transmitters than in nontransmitters (P = .01). In a multivariate model, higher replication capacity was associated with transmission (odds ratio, 1.45 for each 10% increase in replication capacity [95% confidence interval, 1.11-1.90]; P = .0063), after adjustment for maternal HIV-1 load and other factors.


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