Cerebral processing of painful oesophageal stimulation: a study based on independent component analysis of the EEG

Drewes, A. M.; Sami, S. A. K.; Dimcevski, G.; Nielsen, K. D.; Arendt-Nielsen, L.; P. Funch-Jensen; Valeriani, M.
May 2006
Gut;May2006, Vol. 55 Issue 5, p619
Academic Journal
Background and aims: Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus. Methods: Twelve subjects with a median age of 41 years were included. With a nasal endoscope, two series of 35 electrical stimuli at the pain threshold were given to the distal oesophagus and the EEG was subjected to ICA. The sessions were separated by 30 minutes. For each component head models, event related images, spectral perturbation, coherence analysis, and dipoles were extracted. The most valid components were found according to time/frequency information and reliability in both experiments. Results: Reliable components with the most valid dipoles were found in the thalamus, insula, cingulate gyrus, and sensory cortex. Time locked activities were consistent with upstream activation of these areas, and cross coherence analysis of the sources demonstrated dynamic links in the β (14–25 Hz) and γ (25–50 Hz) bands between the suggested networks of neurones. The thalamic components were time and phase locked intermittently, starting around 50 ms. In the cingulate gyrus, the posterior areas were always firstly activated, followed by the middle and anterior regions. Components with dipoles in the sensory cortex were localised in several regions of the somatosensory area. Conclusions: The method gives new information relating to the localisation and dynamics between neuronal networks in the brain to pain evoked from the human oesophagus, and should be used to increase our understanding of clinical pain.


Related Articles

  • Human Cortical Traveling Waves: Dynamical Properties and Correlations with Responses. Patten, Timothy M.; Rennie, Christopher J.; Robinson, Peter A.; Gong, Pulin // PLoS ONE;Jun2012, Vol. 7 Issue 6, p1 

    The spatiotemporal behavior of human EEG oscillations is investigated. Traveling waves in the alpha and theta ranges are found to be common in both prestimulus and poststimulus EEG activity. The dynamical properties of these waves, including their speeds, directions, and durations, are...

  • Characteristics of activation in the parietal areas of the cortex in humans in different types of visual attention. I. Baranov-Krylov; V. Shuvaev; I. Kanunikov // Neuroscience & Behavioral Physiology;May2007, Vol. 37 Issue 4, p331 

    Abstract  The state of cortical activation in the parietal and temporal areas was assessed using evoked potentials (EP) during the tasks of selection of lateralized visual stimuli requiring three different types of attention: to stimulus shape, to stimulus position, and to both. Studies in...

  • Errors in EEG Interpretation: The Viewpoint of a Technologist. Fritz, Sheila C.; Benbadis, Selim R. // American Journal of Electroneurodiagnostic Technology;Sep2009, Vol. 49 Issue 3, p289 

    The article reflects on errors in interpreting an electroencephalography (EEG) which are said to be the major contributor to the misdiagnosis of epilepsy. It says erroneous diagnosis is commonly attributable to simple fluctuations of background activity in the temporal region. It outlines...

  • Localised astroglial dysfunction disrupts high-frequency EEG rhythms. Willoughby, J. O.; Mackenzie, L.; Pope, K. J.; Broberg, M.; Nilsson, M. // Journal of Neural Transmission;Feb2005, Vol. 112 Issue 2, p205 

    We used cerebral cortex injections of fluorocitrate to determine if selective astrocytic disturbances affect the electroencephalogram (EEG). Rats were halothane-anaesthetized and 0.8?nmol of sodium fluorocitrate was injected into hindlimb (motor-sensory) cortex. Extra-dural EEG electrodes were...

  • Transient Synchrony of Distant Brain Areas and Perceptual Switching in Ambiguous Figures. Nakatani, Hironori; van Leeuwen, Cees // Biological Cybernetics;Jun2006, Vol. 94 Issue 6, p445 

    We studied the relationship between perceptual switching in the Necker cube and long-distance transient phase synchronization in EEG. Transient periods of response related synchrony between parietal and frontal areas were observed. They start 800�600, ms prior to the switch response and...

  • Classification Control for Discrimination between Interictal Epileptic and Non -- Epileptic Pathological EEG Events. Papavlasopoulos, Sozon H.; Poulos, Marios S.; Bokos, George D.; Evangelou, Angelos M. // International Journal of Biomedical Sciences;2006, Vol. 1 Issue 1, p34 

    In this study, the problem of discriminating between interictal epileptic and non- epileptic pathological EEG cases, which present episodic loss of consciousness, investigated. We verify the accuracy of the feature extraction method of autocross-correlated coefficients which extracted and...

  • Segmentation of Electroencephalographic Signals using an Optimal Orthogonal Linear Prediction Algorithm. Ursulean, R.; Lazar, A. M. // Electronics & Electrical Engineering;2007, Issue 73, p73 

    Finding the stationary parts of an EEG signal proves to be a difficult task because of the various shapes of the signal that can be found for different subjects, both normal and abnormal. The paper presents the results obtained in the segmentation of an EEG signal into stationary parts in order...

  • Can Continuous EEG Influence Outcome in Patients with Intracerebral Hemorrhage (ICH)? Kandula, Padmaja // Neurology Alert;Nov2007, Vol. 26 Issue 3, p21 

    Since the advent of continuous EEG monitoring (cEEG), medical awareness of electrographic seizures has increased. In a previous retrospective study by Claassen and colleagues, nearly 20% of critically ill patients monitored for unexplained mental status had subclinical seizures. A separate...

  • Time delay of electroencephalogram index calculation: analysis of cerebral state, bispectral, and Narcotrend indices using perioperatively recorded electroencephalographic signals. Zanner, R.; Pilge, S.; Kochs, E. F.; Kreuzer, M.; Schneider, G. // BJA: The British Journal of Anaesthesia;Sep2009, Vol. 103 Issue 3, p394 

    Background: Monitoring of anaesthetic depth with EEG-derived indices may detect EEG changes associated with awareness and thereby help to decrease the incidence of intraoperative awareness with postoperative recall. All currently available monitors need varying time periods to calculate a new...


Read the Article


Sign out of this library

Other Topics