TITLE

Little of no residual prostate cancer at radical prostatectomy

AUTHOR(S)
Kumar, R.; Yadav, R.
PUB. DATE
January 2006
SOURCE
Indian Journal of Urology;Jan-Mar2006, Vol. 22 Issue 1, p83
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Following a needle biopsy diagnosis of prostate cancer, occasionally, no residual cancer can be identified in the radical prostatectomy specimen. Such cancers have been referred to as the 'Vanishing cancer phenomenon'. This raises the question as to whether the initial biopsy and subsequent radical prostatectomy are from the same patient. The authors used a PCR-based micro satellite marker analysis to perform identity test in 46 men, whose radical prostatectomy specimen was reported as 'minute' (n=35) or 'no residual' (n=11) cancer. DNA was isolated from formalin fixed, paraffin embedded blocks of both the biopsy and the prostatectomy specimen and PCR amplification was performed for 9 micro satellite loci. Amplification and comparison was possible in 41 of the 46 specimen. 9 of 11 patients with 'no residual cancer' matched the biopsy specimen, confirming that this report is feasible after radical prostatectomy. 1 of the 11 had uninterpretable result, while 1 did not match the biopsy, implicating a 'switched biopsy' specimen. All cases of 'minute' tumor matched the biopsy specimen. The results confirm. that in most cases of "vanishing cancer" in radical prostatectomy specimens, it reflects a chance sampling of a minute cancer and not a switch in specimens. However, if there is high-grade cancer or a lot of cancer on the biopsy and no or very minimal cancer in the radical prostatectomy specimen, one should evaluate for patient identity, as it could reflect a switched specimen. Factors responsible for "vanishing cancer" could be treatment by preoperative hormone therapy, removal of entire tumor by the biopsy needle, induction of inflammatory process resulting in resolution of the residual cancer, or inability to identify the tumor in the examined glass slides.
ACCESSION #
20714147

 

Related Articles

  • Managing Patients Following a Negative Prostate Biopsy.  // Renal & Urology News;Feb2011, Vol. 10 Issue 2, p23 

    The article addresses several issues affecting the scenario posed by patients who have undergone repeat biopsy for prostate cancer in the U.S. It stresses that urologists need to consider several factors when deciding a repeat biopsy which is more likely to indicate cancer because the previous...

  • PROSTATE CANCER DIAGNOSTICS WITH BIOPSY MATERIAL. Fedorina, T. A.; Poletaeva, S. V. // Saratov Journal of Medical Scientific Research / Saratovskii Nau;Oct-Dec2013, Vol. 9 Issue 4, p632 

    The aim of the article is to study the potential importance of specific location of biopsy of prostate cancer. Material and methods. Histological material from 700 patients has been examinated. 580 specimen of radical prostatectomy were examined. TRUS-guided 12-cores biopsy has been performed in...

  • Perform a follow-up prostate biopsy even when the first is negative.  // Modern Medicine;Oct97, Vol. 65 Issue 10, p10 

    Focuses on the study recommending a second transrectal ultrasound-guided needle biopsy of the prostate when the first biopsy is negative. Target on men with high levels of prostate-specific antigen; Failure to identify small cancers during the first biopsy.

  • Prostat iÄŸne biyopsisi ve radikal prostatektomi materyallerinde gleason skorlarının karşılaÅŸtırılması. Kürşat Bozkurt, Kemal; Kızmaz, Mustafa; İnan Mamak, Gülsün; Korkmaz, İsmail; Bircan, Sema // Medical Journal of Suleyman Demirel University;2013, Vol. 20 Issue 3, p93 

    Aim: Gleason score (GS) is an important prognostic marker for prostate cancer and it is strongly correlated with stage and prognosis. However, needle biopsy (NB) GS is not always consistent with that of radical prostatectomy (RP) specimens. In this study, the correlation of GSs of NB and RP...

  • Diagnostic value of ADC in patients with prostate cancer: influence of the choice of b values. Thörmer, Gregor; Otto, Josephin; Reiss-Zimmermann, Martin; Seiwerts, Matthias; Moche, Michael; Garnov, Nikita; Franz, Toni; Do, Minh; Stolzenburg, Jens-Uwe; Horn, Lars-Christian; Kahn, Thomas; Busse, Harald // European Radiology;Aug2012, Vol. 22 Issue 8, p1820 

    Objectives: To evaluate the influence of the choice of b values on the diagnostic value of the apparent diffusion coefficient (ADC) for detection and grading of prostate cancer (PCa). Methods: Forty-one patients with biopsy-proven PCa underwent endorectal 3-T MRI before prostatectomy. Different...

  • The effect of urologist experience on choosing active surveillance for prostate cancer. Chu, William; Kim, Brian; Slezak, Jeff; Harrison, Teresa; Gelfond, Joy; Jacobsen, Steven; Chien, Gary // World Journal of Urology;Nov2015, Vol. 33 Issue 11, p1701 

    Purpose: To evaluate the impact of the urologist's experience in selecting active surveillance (AS) versus immediate treatment (IT) for low-risk prostate cancer. Methods: Men with low-risk prostate cancer were enrolled from March 2011 to August 2013 at 13 medical centers in Kaiser Permanente...

  • Targeted MRI/TRUS fusion-guided biopsy in men with previous prostate biopsies using a novel registration software and multiparametric MRI PI-RADS scores: first results. Tewes, Susanne; Hueper, Katja; Hartung, Dagmar; Imkamp, Florian; Herrmann, Thomas; Weidemann, Juergen; Renckly, Stefan; Kuczyk, Markus; Wacker, Frank; Peters, Inga // World Journal of Urology;Nov2015, Vol. 33 Issue 11, p1707 

    Purpose: To evaluate a novel system for MRI/TRUS fusion-guided biopsy for detection of prostate cancer (PCa) in patients with previous negative prostate biopsy and determine diagnostic accuracy when using the Prostate Imaging Reporting and Data System (PI-RADS) for multiparametric magnetic...

  • An examination of prostate cancer trends in Australia, England, Canada and USA: Is the Australian death rate too high? Feletto, E.; Bang, A.; Cole-Clark, D.; Chalasani, V.; Rasiah, K.; Smith, D. // World Journal of Urology;Nov2015, Vol. 33 Issue 11, p1677 

    Purpose: To compare prostate cancer incidence and mortality rates in Australia, USA, Canada and England and quantify the gap between observed prostate cancer deaths in Australia and expected deaths, using US mortality rates. Methods: Analysis of age-standardised prostate cancer incidence and...

  • Optimal Biopsy Protocols for Prostate Cancer. Sofer, Ariela; Jianchao Zeng; Mun, Seong K. // Annals of Operations Research;Mar2003, Vol. 119 Issue 1-4, p63 

    Prostate cancer is the second leading cause of cancer-related death among American men. Biopsy for prostate cancer is a procedure known as transrectal ultrasound-guided needle biopsy. Because of the low resolution of ultrasound, the urologist cannot usually distinguish between cancerous and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics