Pre-flight testing of preterm infants with neonatal lung disease: a retrospective review

Udomittipong, K.; Stick, S. M.; Verheggen, M.; Oostryck, J.; Sly, P. D.; Hall, G. I.; Hall, G L
April 2006
Thorax;Apr2006, Vol. 61 Issue 4, p343
Academic Journal
journal article
Background: The low oxygen environment during air travel may result in hypoxia in patients with respiratory disease. However, little information exists on the oxygen requirements of infants with respiratory disease planning to fly. A study was undertaken to identify the clinical factors predictive of an in-flight oxygen requirement from a retrospective review of hypoxia challenge tests (inhalation of 14-15% oxygen for 20 minutes) in infants referred for fitness to fly assessment. Methods: Data from 47 infants (median corrected age 1.4 months) with a history of neonatal lung disease but not receiving supplemental oxygen at the time of hypoxia testing are reported. The neonatal and current clinical information of the infants were analysed in terms of their ability to predict the hypoxia test results. Results: Thirty eight infants (81%) desaturated below 85% and warranted prescription of supplemental in-flight oxygen. Baseline oxygen saturation was >95% in all infants. Age at the time of the hypoxia test, either postmenstrual or corrected, significantly predicted the outcome of the hypoxia test (odds ratio 0.82; 95% confidence intervals 0.62 to 0.95; p = 0.005). Children passing the hypoxia test were significantly older than those requiring in-flight oxygen (median corrected age (10-90th centiles) 12.7 (3.0-43.4) v 0 (-0.9-10.9) months; p < 0.0001). Conclusions: A high proportion of ex-preterm infants not currently requiring supplemental oxygen referred for fitness-to-fly assessment and less than 12 months corrected age are at a high risk of requiring in-flight oxygen. Referral of this patient group for fitness to fly assessment including a hypoxia test may be indicated.


Related Articles

  • Cardiovascular function in children who had chronic lung disease of prematurity. Joshi, Suchita; Wilson, Dirk G.; Kotecha, Sarah; Pickerd, Nicole; Fraser, Alan G.; Kotecha, Sailesh // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Sep2014, Vol. 99 Issue 5, pF373 

    Objectives: Although increased pulmonary arterial pressure is common in infancy in preterm infants who develop chronic lung disease of prematurity (CLD), it is unknown if the increase persists into childhood. We, therefore, assessed if 8-12-year-old children with documented CLD in infancy had...

  • Assessment of hypoxia in children with cystic fibrosis. Urquhart, D. S.; Montgomery, H.; Jaffé, A. // Archives of Disease in Childhood;Nov2005, Vol. 90 Issue 11, p1138 

    Hypoxia during sleep and exercise may occur in an important number of patients with cystic fibrosis (CF). Despite its recognition, no clear definition for hypoxia in CF exists, and nor do guidelines for commencing oxygen therapy. CF patients with hypoxia may have increased pulmonary artery...

  • Blood transfusion and chronic lung disease in preterm infants. Cooke, R. W. I.; Drury, J. A.; Yoxall, C. W.; James, C. // European Journal of Pediatrics;1997, Vol. 156 Issue 1, p47 

    Frequent blood transfusions may produce changes in iron status which can give rise to oxygen-derived free-radical (ODFR) generation and oxidative injury. Preterm infants developing chronic lung disease (CLD) receive significantly more transfusions. A total of 73 very preterm infants had weekly...

  • Inhaled nitric oxide does not increase lipid peroxidation in preterm infants. Drury, J. A.; Nycyk, J. A.; Subhedar, N. V.; Shaw, N. J.; Cooke, R. W. I. // European Journal of Pediatrics;1998, Vol. 157 Issue 12, p1033 

    Presents a randomized controlled trial of treatment with inhaled nitric oxide (INO) therapy and intravenous dexamethasone in preterm infants at risk of developing chronic lung disease. Concern on the introduction of INO; Comparison of oxygenation index between infants in the INO group and...

  • Hypoxemia during air travel in patients with chronic obstructive pulmonary disease. Dillard, Thomas A.; Berg, Benjamin W.; Rajagopal, Krishnan R.; Dooley, James W.; Mehm, William J.; Dillard, T A; Berg, B W; Rajagopal, K R; Dooley, J W; Mehm, W J // Annals of Internal Medicine;9/1/89, Vol. 111 Issue 5, p362 

    Study Objective: To quantitate and identify determinants of the severity of hypoxemia during air travel in patients with chronic obstructive pulmonary disease. Design: Prospective study of physiologic variables before and during intervention. Setting:...

  • Apnea, intermittent hypoxia and blood transfusions: it works, but now what? Eichenwald, E C // Journal of Perinatology;Dec2014, Vol. 34 Issue 12, p881 

    An introduction is presented in which the editor discusses various reports within the issue including red blood transfusions in anemic premature infants, association of apnea and anemia and neurodevelopmental in preterm infants.

  • Serum bilirubin and development of chronic lung disease in very low birth weight infants. Schrod, L.; von Stockhausen, H.-B. // European Journal of Pediatrics;1999, Vol. 158 Issue 2, p169 

    Evaluates bilirubin concentrations in premature infants with low birth weights to examine the correlation of oxidative stress markers in tracheobronchial aspirates and the development of chronic lung disease. Role of oxidative injury in the pathogenesis of chronic lung disease; ion on the Total...

  • Otuz haftalık prematüre bir olguda geliÅŸen rezistan atelektazide rhDNase kullanımı. KUŞKAYA, Midhat // Journal of Dr. Behcet Uz Children's Hospital; 

    Atelectasis is defined as partial or complete collapse of one lung. This condition generally accompanies many lung or chest diseases, and becomes manifest with the symptoms of the underlying disease. Mucous plugs contain a lot of deoxyribonucleic acid (DNA). Recombinant human DNase (rhDNase)...

  • Role of Erythromycin for Treatment of Incipient Chronic Lung Disease in Preterm Infants Colonised with Ureaplasma urealyticum. Buhrer, C.; Hoehn, T.; Hentschel, J. // Drugs;Oct2001, Vol. 61 Issue 13, p1893 

    Ureaplasma urealyticum is frequently isolated from tracheal aspirates of very low birthweight infants who go on to develop chronic lung disease. The use of erythromycin has been advocated in ventilated very low birthweight infants who are colonised with U. urealyticum, although the association...


Read the Article


Sign out of this library

Other Topics