Standish, R. A.; Cholongitas, E.; Dhillon, A.; Burroughs, A. K.; Dhillon, A. P.
April 2006
Gut;Apr2006, Vol. 55 Issue 4, p569
Academic Journal
One of the most important aspects of the histopathological assessment of liver biopsies in the setting of chronic liver disease is determination of the degree of fibrosis and architectural change. Most of the work in this regard has been concerned with chronic viral hepatitis. This article attempts to assess critically our current and historical biopsy practice, from subjective fibrosis scoring systems to biopsy sample size; and the appropriate use of the data that scoring systems generate in the research and clinical setting. An understanding of the limitations of each of the components of the fibrosis assessment process can help to devise appropriate protocols to ensure that the information obtained is optimised, and its degree of reliability appreciated. It is only from this starting point that recently promulgated antifibrotic medication and "non-invasive" liver fibrosis assessment techniques can be evaluated properly.


Related Articles

  • Accuracy of Routine Clinical Ultrasound for Staging of Liver Fibrosis. Chih-Ching Choong; Venkatesh, Sudhakar K.; Siew, Edwin P. Y. // Journal of Clinical Imaging Science;Jan-Mar2012, Vol. 2 Issue 1, Special section p1 

    Objective: To determine the diagnostic accuracy of routine clinical ultrasound in the staging of liver fibrosis in chronic viral hepatitis. Materials and Methods: A retrospective evaluation of the ultrasound images of 156 patients with chronic viral hepatitis who underwent liver biopsy was...

  • Phylogenetic analysis and subtyping of acute and fulminant strains of hepatitis E virus isolates of North India with reference to disease severity. Pujhari, Sujit Kumar; Kumar, Subrat; Ratho, Radha Kanta; Chawla, Yogesh Kumar; Chakraborti, Anuradha // Archives of Virology;Sep2010, Vol. 155 Issue 9, p1483 

    Hepatitis E is endemic to the Indian subcontinent, with a seroprevalence of 4-20%, and more than 25% of acute viral hepatitis is due to HEV. The northern parts of India have been experiencing outbreaks and sporadic cases of HEV since 1955. In a total of sixteen HEV sequences, ten acute viral...

  • Liver histology according to the presence of metabolic syndrome in nonalcoholic fatty liver disease cases. Uslusoy, Hüseyin Saadettin; Nak, Selim Giray; Gülten, Macit; Bıyıklı, Zeynep; Torbenson, Michael; Ishikawa, Toru // World Journal of Gastroenterology;3/7/2009, Vol. 15 Issue 9, p1093 

    AIM: To investigate the histologic features of the liver in nonalcoholic fatty liver disease (NAFLD) cases according to the presence of metabolic syndrome or its individual components. METHODS: We enrolled 81 patients (40 male, 41 female) who were diagnosed with liver by ultrasonographic scan...

  • NON-INVASIVE MARKERS OF HEPATIC FIBROSIS IN CHRONIC HEPATITIS B: A REVIEW. Rahman, Salimur; Khan, Mobin // Hepatitis B Annual;2007, Vol. 4, p61 

    Assessment of fibrosis is important in chronic hepatitis B for a number of reasons including decision-making regarding treatment and predicting prognosis. Currently liver biopsy is considered the gold standard for assessing liver histology. However, since liver biopsy has significant...

  • Hepatitis B in Moroccan health care workers. K. Djeriri; H. Laurichesse; J. L. Merle; R. Charof; A. Abouyoub; L. Fontana; N. Benchemsi; E. Elharti; R. El Aouad; A. Chamoux; J. Beytout // Occupational Medicine;Sep2008, Vol. 58 Issue 6, p419 

    Aim To evaluate knowledge and perception of hepatitis B, including prevention, among Moroccan health care workers (HCWs) and to estimate seroprevalence of hepatitis B and vaccine coverage (VC). Methods Four hundred and twenty HCWs were randomly selected and stratified by site: 120 in Rabat, 140...

  • Levels and values of circulating endothelial progenitor cells, soluble angiogenic factors, and mononuclear cell apoptosis in liver cirrhosis patients. Chih-Hung Chen; Li-Teh Chang; Wei-Chih Tung; Yung-Lung Chen; Chia-Lo Chang; Leu, Steve; Cheuk-Kwan Sun; Tzu-Hsien Tsai; I-Ting Tsai; Hsueh-Wen Chang; Hon-Kan Yip // Journal of Biomedical Science;2012, Vol. 19 Issue 1, p66 

    Background: The roles of circulating endothelial progenitor cell (EPC) and mononuclear cell apoptosis (MCA) in liver cirrhosis (LC) patients are unknown. Moreover, vascular endothelial growth factor (VEGF) and stromal cell-derived factor (SDF)-1α are powerful endogenous substances enhancing...

  • Viral Hepatitis; Evaluation by Means of Radioisotopes. Schwartz, Raphael D.; Herrera, Nilo K. // American Journal of Gastroenterology;Sep1967, Vol. 48 Issue 3, p204 

    Using a technic described in our laboratory which simultaneously measures the functional and morphologic status of the liver by means of radioactive Rose Bengal, we have had the opportunity of serially studying three patients with viral hepatitis over a four-, six- and 15-month period...

  • PREDVIĐANJE CIROZE STANDARDNIM LABORATORIJSKIM PARAMETRIMA KOD BOLESNIKA SA HRONIÄŒNOM HEPATITIS C VIRUSNOM INFEKCIJOM. Švitlih, Neda; DeliĆ, Dragan; SimonoviĆ-BabiĆ, Jasmina; MaksĆ, Nebojša; GvozdenoviĆ, Eleonora; DokiĆ, Ljubiša; BoriĆiĆ, Ivan; PaviĆ, Slađana; DraškoviĆ, Dragica; NešiĆ, Zorica // Jugoslovenska Medicinska Biohemija / Yugoslav Medical Biochemist;Sep2006, Vol. 25 Issue 3, p255 

    Total of 153 patients with chronic Hepatitis C Virus infection was investigated. Patients were classified into three groups: with histologic confirmed liver cirrhosis, clinical advanced cirrhosis, and chronic hepatitis without fibrosis. Acitivity of aminotransferases (AST, ALT), value of INR and...

  • Immunopathogenesis of hepatitis B virus infection. Chang, J Judy; Lewin, Sharon R // Immunology & Cell Biology;Jan2007, Vol. 85 Issue 1, p16 

    Hepatitis B virus (HBV) infection is a non-cytopathic hepatotropic virus that can lead to severe liver disease including acute hepatitis, cirrhosis and hepatocellular carcinoma. Successful clearance of the virus as well as the establishment of liver disease is largely driven by a complex...


Read the Article


Sign out of this library

Other Topics