TITLE

MOLECULAR INSIGHTS INTO THE PATHOGENESIS OF HEREDITARY HAEMOCHROMATOSIS

AUTHOR(S)
Pietrangelo, A.
PUB. DATE
April 2006
SOURCE
Gut;Apr2006, Vol. 55 Issue 4, p564
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses a pathogenic model for hemochromatosis (HC), an autosomal recessive disorder of iron metabolism characterized by tissue iron overload potentially leading to multiorgan disease. It details the functions of four HC genes: HFE, transferrin receptor 2, HJV and HAMP. It also examines the role of the interaction of HFE with transferrin receptor 1 genes in the pathogenesis of HC.
ACCESSION #
20509035

 

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