TITLE

Immunosuppressive drugs in ulcerative colitis: twisting facts to suit theories?

AUTHOR(S)
Sands, B. E.
PUB. DATE
April 2006
SOURCE
Gut;Apr2006, Vol. 55 Issue 4, p437
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Immunosuppressive drugs have become a mainstay of therapy far the inflammatory bowel diseases, Although robust evidence exists in support of the use of these drugs in Crohn's disease, a close evaluation of the available data in ulcerative colitis reveals a much weaker evidence base. In particular, randomised controlled trials of azathioprine, the most commonly used immunosuppressive agent, do not provide rich evidence of efficacy whereas observational cohorts suggest this agent is effective, particularly in patients with relapsing disease !ho require corticosteroids. Ciclosporin is also effective in the most refractory cases hut its efficacy needs to be carefully weighed against the possibility of rare but life threatening complications. Although the evidence base in support of immunosuppressive drugs in ulcerative colitis is not as strong as in Crohn's disease, these agents clearly have a role in the treatment of this disease.
ACCESSION #
20509007

 

Related Articles

  • Immunosuppressant Medications and Mortality in Inflammatory Bowel Disease. Lewis, James D.; Gelfand, Joel M.; Troxel, Andrea B.; Forde, Kimberly A.; Newcomb, Craig; Kim, Hopiy; Margolis, David J.; Strom, Brian L. // American Journal of Gastroenterology;Jun2008, Vol. 103 Issue 6, p1428 

    OBJECTIVE: This study examined whether treatment of Crohn's disease (CD) and ulcerative colitis (UC) with immunosuppressant medications was associated with an increased risk of death in the era prior to antitumor necrosis factor (TNF) therapies. DESIGN: This retrospective cohort study used data...

  • Can Calprotectin Predict Relapse Risk in Inflammatory Bowel Disease? D'Inc, Renata; Dal Pont, Elisabetta; Di Leo, Vincenza; Benazzato, Luca; Martinato, Matteo; Lamboglia, Francesca; Oliva, Lydia; Carlo Sturniolo, Giacomo // American Journal of Gastroenterology;Aug2008, Vol. 103 Issue 8, p2007 

    OBJECTIVE: Assessing the clinical course of inflammatory bowel disease (IBD) patients consists of periodical clinical evaluations and laboratory tests. We aimed to assess the role of calprotectin tests in predicting clinical relapse in IBD patients. METHODS: Ninety-seven patients with ulcerative...

  • Immunization status in children with inflammatory bowel disease. Longuet, Romain; Willot, Stephanie; Giniès, Jean-Louis; Pélatan, Cecile; Breton, Estelle; Segura, Jean-François; Bridoux, Laure; Henaff, Gaelle; Cagnard, Benoit; Jobert, Agathe; Cardonna, Joël; Grimal, Isabelle; Balençon, Martine; Darviot, Estelle; Delaperrière, Nadège; Caldari, Dominique; Piloquet, Hugues; Dabadie, Alain // European Journal of Pediatrics;May2014, Vol. 173 Issue 5, p603 

    Inflammatory bowel diseases have an increased risk of infections due to immunosuppressive therapies. To report the immunization status according to previous recommendations and the reasons explaining a delay, a questionnaire was filled in by the pediatric gastroenterologist, concerning...

  • Biologies can treat some cases of inflammatory bowel disease. Zablocki, Elaine // Managed Healthcare Executive;Dec2009, Vol. 19 Issue 12, p25 

    The article discusses the inflammatory bowel disease (IBD) in the U.S. in which the intestines become inflamed as a result of immune reaction mobilized against intestinal tissue. It notes that ulcerative colitis affects the rectum and colon while Crohn's disease affects the gastrointestinal...

  • Digestive Disease Week 2011: An Update on IBD Clinical Research. Hoentjen, Frank // Inflammatory Bowel Disease Monitor;2011, Vol. 12 Issue 1, p42 

    Information about several papers discussed at a meeting held May 7-10, 2011 sponsored by University of Chicago Department of Medicine on biological therapy for inflammatory bowel disease (IBD) is presented. Topics include immunosuppressive therapy for patients with Crohn's disease, the use of...

  • Use of mycophenolate mofetil in inflammatory bowel disease. Tan, Terrence; Lawrance, Ian Craig; Koutroubakis, Ioannis E. // World Journal of Gastroenterology;4/7/2009, Vol. 15 Issue 13, p1594 

    AIM: To assess the efficacy and safety of mycophenolate mofetil (MMF) prospectively in inflammatory bowel disease (IBD) patients intolerant or refractory to conventional medical therapy. METHODS: Crohn's disease (CD) or ulcerative colitis/IBD unclassified (UC/IBDU) patients intolerant or...

  • Cyclosporine and inflammatory bowel disease: buying time. Meijssen, M. A. C. // Mediators of Inflammation;Jun98, Vol. 7 Issue 3, p145 

    CYCLOSPORINE is an effective drug in acute exacerbations of corticosteroid resistant ulcerative colitis, but its efficacy to maintain disease remission is not clear. Cyclosporine may not be as effective in Crohn's disease. However, being a rapidly acting immunosuppressant, cyclosporine may be a...

  • Diet and relapsing ulcerative colitis: take off the meat? Tilg, H.; Kaser, A. // Gut;Oct2004, Vol. 53 Issue 10, p1399 

    This article reports on the association of dietary factors such as red meat, high protein intake, and alcohol with relapse in ulcerative colitis. Major advances in the understanding of the aetiopathogenesis and genetics of inflammatory bowel disease have been accompanied by an increase in the...

  • Patients with Inflammatory Bowel Disease Have a Lower Response Rate to HBV Vaccination Compared to Controls. Altunöz, Mustafa; Şenateş, Ebubekir; Yeşil, Atakan; Çalhan, Turan; Övünç, Ayşe // Digestive Diseases & Sciences;Apr2012, Vol. 57 Issue 4, p1039 

    Background: Hepatitis B (HBV) is a vaccine-preventable infection that may cause severe infections, particularly in patients who are being treated with immunosuppressive therapy [(i.e., inflammatory bowel disease (IBD)]. Limited data are available about IBD patients' response rate to HBV vaccine....

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics