TITLE

Neutralized Lidocaine with Epinephrine for Local Anesthesia--II

AUTHOR(S)
Stewart, James H.; Chinn, Susan E.; Cole, Gary W.; Klein, Jeffrey A.
PUB. DATE
September 1990
SOURCE
Journal of Dermatologic Surgery & Oncology;Sep90, Vol. 16 Issue 9, p842
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The pain usually associated with intradermal injection of lidocaine and epinephrine is significantly attenuated by the addition of either sodium bicarbonate or sodium hydroxide to 1% lidocaine with epinephrine. This suggests that sodium bicarbonate attenuates pain by increasing the pH of the anesthetic solution. The clinical effects of a solution of lidocaine (1%) with epinephrine (1:100,000) and sodium bicarbonate (80 meq/L) were assessed after infiltration in skin. Anesthetic stored for 1 week caused nearly equal areas of anesthesia and vasoconstriction as an identical solution prepared on the day of use.
ACCESSION #
20444120

 

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