High Risk of Cardiovascular Disease in Patients With Type 1 Diabetes in the U.K

Soedamah-Muthu, Sabita S.; Fuller, John H.; Mulnier, Henrietta E.; Raleigh, Veena S.; Lawrenson, Ross A.; Colhoun, Helen M.
April 2006
Diabetes Care;Apr2006, Vol. 29 Issue 4, p798
Academic Journal
OBJECTIVE -- To estimate the absolute and relative risk of cardiovascular disease (CVD) in patients with type 1 diabetes in the U.K. RESEARCH DESIGN AND METHODS -- Subjects with type 1 diabetes (n = 7,479) and five age- and sex-matched subjects without diabetes (n = 38,116) and free of CVD at baseline were selected from the General Practice Research Database (GPRD), a large primary care database representative of the U.K. population. Incident major CVD events, comprising myocardial infarction, acute coronary heart disease death, coronary revascularizations, or stroke, were captured for the period 1992-1999. RESULTS -- The hazard ratio (HR) for major CVD was 3.6 (95% CI 2.9-4.5) in type 1 diabetic men compared with those without diabetes and 7.7 (5.5-10.7) in women. Increased HRs were found for acute coronary events (3.0 and 7.6 in type 1 diabetic men and women, respectively, versus nondiabetic subjects), coronary revascularizations (5.0 in men, 16.8 in women), and for stroke (3.7 in men, 4.8 in women). Type 1 diabetic men aged 45-55 years had an absolute CVD risk similar to that of men in the general population 10-15 years older, with an even greater difference in women. CONCLUSIONS -- Despite advances in care, these data show that absolute and relative risks of CVD remain extremely high in patients with type 1 diabetes. Women with type 1 diabetes continue to experience greater relative risks of CVD than men compared with those without diabetes.


Related Articles

  • Take Your Diabetes to Heart. Edelman, Steven // Diabetes Health;Aug2004, Vol. 13 Issue 8, p14 

    Focuses on heart disease in people with diabetes. Information on life-saving therapies for cardiovascular diseases; Ways to prevent heart disease; Symptoms of myocardial ischemia.

  • Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481].  // Cardiovascular Diabetology;2005, Vol. 4, p13 

    Objective: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study is examining the effects of long-term fibrate therapy on coronary heart disease (CHD) event rates in patients with diabetes mellitus. This article describes the trial's run-in phase and patients' baseline...

  • Screening for Coronary Artery Disease in Patients With Diabetes. Roelker, Eve // Diabetes Spectrum;Summer2008, Vol. 21 Issue 3, p166 

    Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with diabetes. Consequently, proper screening and diagnosis of CAD is crucial for the prevention and early treatment of coronary events. This review explains the variety of diagnostic exams available for...

  • CARDIOVASCULAR DISEASE & TYPE 1 DIABETES.  // Countdown;Spring2005, Vol. 26 Issue 2, p28 

    The article cites a research on the strong correlation of cardiovascular disease and type 2 diabetes. Previous research revealed the similar correlation between type 1 diabetes and cardiovascular risks. Heart disease and stroke are identified as the post significant problems for people with type...

  • The Link Between DIABETES And CARDIOVASCULAR DISEASE.  // Ebony;Mar2004, Vol. 59 Issue 5, p96 

    Focuses on the link between diabetes and cardiovascular disease (CVD). Discussion on CVD as the leading cause of death among diabetics; Risks of CVD to people with diabetes, such as smoking; Prevention and treatment to lower risk of CVD to people with diabetes.

  • Gender Difference in the Impact of Type 2 Diabetes on Coronary Heart Disease Risk. Juutilainen, Auni; Kortelainen, Saara; Lehto, Seppo; Rönnemaa, Tapani; Pyörälä, Kalevi; Laakso, Markku // Diabetes Care;Dec2004, Vol. 27 Issue 12, p2898 

    OBJECTIVE -- To explain the stronger effect of type 2 diabetes on the risk of coronary heart disease (CHD) in women compared with men. RESEARCH DESIGN AND METHODS -- The study population consisted of 1,296 nondiabetic subjects and 835 type 2 diabetic subjects aged 45-64 years without...

  • Reflex and Tonic Autonomic Markers for Risk Stratification in Patients With Type 2 Diabetes Surviving Acute Myocardial Infarction. BARTHEL, PETRA; BAUER, AXEL; MÜLLER, ALEXANDER; JUNK, NADINE; HUSTER, KATHARINA M.; ULM, KURT; MALIK, MAREK; SCHMIDT, GEORG // Diabetes Care;Aug2011, Vol. 34 Issue 8, p1833 

    OBJECTIVE--Diabetic postinfarction patients are at increased mortality risk compared with nondiabetic postinfarction patients. In a substantial number of these patients, diabetic cardiac neuropathy already preexists at the time of the infarction. In the current study we investigated if markers...

  • Can a chronic care model collaborative reduce heart disease risk in patients with diabetes? Vargas, Roberto B.; Mangione, Carol M.; Asch, Steven; Keesey, Joan; Rosen, Mayde; Schonlau, Matthias; Keeler, Emmett B. // JGIM: Journal of General Internal Medicine;Feb2007, Vol. 22 Issue 2, p215 

    Background: There is a need to identify effective practical interventions to decrease cardiovascular disease risk in patients with diabetes.Objective: We examine the impact of participation in a collaborative implementing the chronic care model (CCM) on the reduction of...

  • NT-pro-BNP measured at discharge predicts outcome in multimorbid diabetic inpatients with a broad spectrum of cardiovascular disease. Pfister, R.; Tan, D.; Thekkanal, J.; Hellmich, M.; Erdmann, E.; Schneider, C. A. // Acta Diabetologica;Jun2007, Vol. 44 Issue 2, p91 

    The prognostic value of NT-pro-BNP has not been thoroughly evaluated in diabetic inpatients with manifest cardiovascular disease. NT-pro-BNP was measured in 156 patients with type 2 diabetes mellitus hospitalised due to cardiovascular disease. The association of NT-pro-BNP with mortality and the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics