Lack of Association between Infection with a Novel Human Coronavirus (HCoV), HCoV-NH, and Kawasaki Disease in Taiwan

Luan-Yin Chang; Bor-Luen Chiang; Chuan-Liang Kao; Mei-Hwan Wu; Pei-Jer Chen; Berkhout, Ben; Hui-Ching Yang; Li-Min Huang
January 2006
Journal of Infectious Diseases;1/15/2006, Vol. 193 Issue 2, p283
Academic Journal
We investigated whether infection with a novel human coronavirus (HCoV), called ‘New Haven coronavirus’ (HCoV-NH)-which is similar to and likely represents the same species as another novel HCoV, HCoV-NL63-is associated with Kawasaki disease (KD) in Taiwan. Fifty-three patients with KD were enrolled in our study. Serum, peripheral-blood mononuclear cells, nasopharyngeal aspirates, throat swabs, and rectal swabs from these patients were assayed for HCoV-NL63 by real-time reverse-transcriptase (RT) polymerase chain reaction (PCR), and the throat swabs, nasopharyngeal aspirates, and rectal swabs were also assayed for HCoV-NH by RT-PCR. All PCR results were negative for both HCoV-NL63 and HCoV-NH; therefore, we did not find any association between HCoV-NH infection and KD in Taiwan.


Related Articles

  • Human Coronavirus NL63 Is Not Detected in the Respiratory Tracts of Children with Acute Kawasaki Disease. Shimizu, Chisato; Shike, Hiroko; Baker, Susan C.; Garcia, Francesca; van der Hoek, Lia; Kuijpers, Taco W.; Reed, Sharon L.; Rowley, Anne H.; Shulman, Stanford T.; Talbot, Helen K. B.; Williams, John V.; Burns, Jane C. // Journal of Infectious Diseases;11/15/2005, Vol. 192 Issue 10, p1767 

    Kawasaki disease (KD) is a self-limited, systemic vasculitis of children for which an infectious trigger is suspected. Recently, an association between KD and human coronavirus (HCoV)-New Haven (NH) was reported, on the basis of polymerase chain reaction (PCR) with primers that also amplified...

  • Blinded Case-Control Study of the Relationship between Human Coronavirus NL63 and Kawasaki Syndrome. Dominguez, Samuel R.; Anderson, Marsha S.; Glodé, Mary P.; Robinson, Christine C.; Holmes, Kathryn V. // Journal of Infectious Diseases;12/15/2006, Vol. 194 Issue 12, p1697 

    We conducted a blinded, case-control, retrospective study in pediatric patients hospitalized at The Children's Hospital, Denver, Colorado, to determine whether human coronavirus (HCoV)—NL63 infection is associated with Kawasaki syndrome (KS). Over the course of a 7-month period,...

  • Twenty-five types of T-cell receptor Vβ family repertoire in patients with Kawasaki syndrome. Nomura, Y.; Masuda, K.; Shinkoda, Y.; Sameshima, K.; Oku, S.; Yoshinaga, M.; Miyata, K. // European Journal of Pediatrics;1998, Vol. 157 Issue 12, p981 

    Abstract Recently, a possible relationship between Kawasaki syndrome (KS) and superantigen has been discussed since the report of selective expansion of specific V beta family in the acute phase of KS. To further investigate the relationship between KS and superantigens, we examined 25 types of...

  • Lack of CD4CD25FOXP3 regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki disease. Hirabayashi, Yu; Takahashi, Yoshiyuki; Xu, Yinyan; Akane, Kazuyuki; Villalobos, Itzel; Okuno, Yusuke; Hasegawa, Shinji; Muramatsu, Hideki; Hama, Asahito; Kato, Taichi; Kojima, Seiji // European Journal of Pediatrics;Jun2013, Vol. 172 Issue 6, p833 

    The aim of this study was to investigate changes in CD4CD25FOXP3 regulatory T cells (Tregs) throughout the clinical course of Kawasaki disease (KD) and correlations with response to intravenous immunoglobulin (IVIg) therapy. Participants comprised 18 patients who fulfilled the diagnostic...

  • Differential gene expression of S100 protein family in leukocytes from patients with Kawasaki disease. Ebihara, Takashi; Endo, Rika; Kikuta, Hideaki; Ishiguro, Nobuhisa; Xiaoming Ma; Shimazu, Mitsunobu; Otoguro, Takao; Kobayashi, Kunihiko; Ma, Xiaoming // European Journal of Pediatrics;Jul2005, Vol. 164 Issue 7, p427 

    Unlabelled: S100 family proteins are calcium-binding proteins, some of which have been shown to have intracellular and extracellular functions associated with inflammation. The serum concentration of S100A12 has been reported to increase in the acute phase of Kawasaki disease. The...

  • Isolation of Kawasaki disease-associated with bacterial sequence from peripheral blood leukocytes. Rezai, M. S.; Siadati, S. A.; Khotaei, GH.; Mamishi, S.; Sabuni, F.; Poorakbari, B.; Pajhand, O. // Journal of Mazandaran University of Medical Sciences (JMUMS);2008, Vol. 18 Issue 64, p3 

    Background and Purpose: The clinical and epidemiologic features of Kawasaki disease (KD) suggest an infectious etiology; however, the agent(s) remain unknown. Our purpose was to isolate the causative bacterial gene from peripheral blood leukocytes of patients with acute KD, by Universal...

  • Human Adenovirus Infection in Kawasaki Disease: A Confounding Bystander? Jaggi, Preeti; Kajon, Adriana E.; Mejias, Asuncion; Ramilo, Octavio; Leber, Amy // Clinical Infectious Diseases;Jan2013, Vol. 56 Issue 1, p58 

    In Kawasaki disease (KD), molecular-based detection of human adenovirus (HAdV) infection is not uncommon, may represent persistence of HAdV-C, and should be interpreted with caution. Together, quantitative polymerase chain reaction and HAdV typing may aid in distinguishing HAdV disease mimicking...

  • High incidence of angiotensin I converting enzyme genotype II in Kawasaki disease patients with coronary aneurysm. Takeuchi, K.; Yamamoto, K.; Kataoka, S.; Tanaka, T. Kakihara A.; Sato, S.; Uchiyama, M. // European Journal of Pediatrics;1997, Vol. 156 Issue 4, p266 

    A 287 base pair insertion/deletion polymorphism in intron 16 of the angiotensin I converting enzyme (ACE) gene was examined by polymerase chain reaction in 36 Kawasaki disease patients (16 without coronary aneurysm, 20 with coronary aneurysm). A polymorphism in the ACE gene was characterized by...

  • Kawasaki Disease in Association with Urinary Tract Infection. Kumar, Vivek; Sodhi, Kiran // Indian Pediatrics;Feb2012, Vol. 49 Issue 2, p160 

    A letter to the editor is presented in response to an article about cases of Kawasaki disease with urinary tract infection in a 2011 issue.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics