Colonic Bacterial Infection Abrogates Eosinophilic Pulmonary Disease

Williams, Andrew E.; Edwards, Lorna; Hussell, Tracy
January 2006
Journal of Infectious Diseases;1/15/2006, Vol. 193 Issue 2, p223
Academic Journal
Induction of immunity to one pathogen in the lungs modifies the microenvironment and alters immuno-pathological changes that result from a second, unrelated pulmonary infection. However, it is unclear whether immunity generated at distant sites also affects lung immune responses. Here, we show that infection with the gut-restricted bacterium Citrobacter rodentium modifies immunopathological changes that result from pulmonary Cryptococcus neoformans infection. Th2 cytokine-driven pulmonary eosinophilia induced by C. neoformans infection was reduced, and the enhanced Th1 cytokine environment afforded more-rapid clearance of the fungus in C. rodentium-immune mice. The activated and intraepithelial (CD103+) T cell populations that expand after C. neoformans infection were diminished in C. rodentium-immune mice. T cell cross-reactivity was absent, but cross-reactive antibodies were detected. It is of importance to the ‘hygiene hypothesis’ that these data indicate that an immune response induced by a gut-restricted pathogen can modify the immune outcome after pulmonary infection, suggesting that cell-phenotype modifications occur across mucosal sites.


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