TITLE

Colonic Bacterial Infection Abrogates Eosinophilic Pulmonary Disease

AUTHOR(S)
Williams, Andrew E.; Edwards, Lorna; Hussell, Tracy
PUB. DATE
January 2006
SOURCE
Journal of Infectious Diseases;1/15/2006, Vol. 193 Issue 2, p223
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Induction of immunity to one pathogen in the lungs modifies the microenvironment and alters immuno-pathological changes that result from a second, unrelated pulmonary infection. However, it is unclear whether immunity generated at distant sites also affects lung immune responses. Here, we show that infection with the gut-restricted bacterium Citrobacter rodentium modifies immunopathological changes that result from pulmonary Cryptococcus neoformans infection. Th2 cytokine-driven pulmonary eosinophilia induced by C. neoformans infection was reduced, and the enhanced Th1 cytokine environment afforded more-rapid clearance of the fungus in C. rodentium-immune mice. The activated and intraepithelial (CD103+) T cell populations that expand after C. neoformans infection were diminished in C. rodentium-immune mice. T cell cross-reactivity was absent, but cross-reactive antibodies were detected. It is of importance to the ‘hygiene hypothesis’ that these data indicate that an immune response induced by a gut-restricted pathogen can modify the immune outcome after pulmonary infection, suggesting that cell-phenotype modifications occur across mucosal sites.
ACCESSION #
20371919

 

Related Articles

  • T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis. Piehler, D; Grahnert, A; Eschke, M; Richter, T; Köhler, G; Stenzel, W; Alber, G // Mucosal Immunology (1933-0219);Mar2013, Vol. 6 Issue 2, p405 

    Interleukin (IL)-33 enhances T helper (Th)2 immunity via its receptor T1/ST2. Infection with the yeast-like pathogen Cryptococcus neoformans is usually controlled by a Th1-mediated immune response. The mechanisms responsible for nonprotective Th2 immunity leading to allergic inflammation in...

  • Insights into the Mechanisms of Protective Immunity against Cryptococcus neoformans Infection Using a Mouse Model of Pulmonary Cryptococcosis. Wozniak, Karen L.; Ravi, Sailatha; Macias, Sandra; Young, Mattie L.; Olszewski, Michal A.; Steele, Chad; Wormley Jr., Floyd L. // PLoS ONE;2009, Vol. 4 Issue 9, p1 

    Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening pneumonia and meningoencephalitis in immune compromised individuals. Previous studies have shown that immunization of BALB/c mice with an IFNc- producing C. neoformans strain, H99γ, results in complete...

  • Role of IL-17A on Resolution of Pulmonary C. neoformans Infection. Wozniak, Karen L.; Hardison, Sarah E.; Kolls, Jay K.; Wormley, Jr., Floyd L. // PLoS ONE;2011, Vol. 6 Issue 2, p1 

    The current studies evaluated the role of interleukin (IL)-17A in the induction of protective immunity against pulmonary cryptococcosis in mice. Protection against pulmonary infection with C. neoformans strain H99γ was associated with increased IL-17A production. Signaling through the IFN-c...

  • Contribution of Natural Killer Cells to the Pathogenesis of Septic Shock Induced by Streptococcus pyogenes in Mice. Goldmann, Oliver; Chhatwal, Gursharan S.; Medina, Eva // Journal of Infectious Diseases;4/15/2005, Vol. 191 Issue 8, p1280 

    Natural killer (NK) cells are critical components of the innate immune system and have been implicated in the pathogenesis of septic shock. In the present study, the relative contribution of NK cells to the development of Streptococcus pyogenes-induced septic shock was investigated in a mouse...

  • Mast cell dipeptidyl peptidase I mediates survival from sepsis. Clair, Jon Mallen-St.; Pham, Christine T. N.; Villalta, S. Armando; Caughey, George H.; Wolters, Paul J. // Journal of Clinical Investigation;Feb2004, Vol. 113 Issue 4, p628 

    Sepsis is a common, life-threatening disease for which there is little treatment. The cysteine protease dipeptidyl peptidase I (DPPI) activates granule-associated serine proteases, several of which play important roles in host responses to bacterial infection. To examine DPPI's role in sepsis,...

  • A critical role of Dectin-1 in hypersensitivity pneumonitis. Higashino-Kameda, Mari; Yabe-Wada, Toshiki; Matsuba, Shintaro; Takeda, Kazuya; Anzawa, Kazushi; Mochizuki, Takashi; Makimura, Koichi; Saijo, Shinobu; Iwakura, Yoichiro; Toga, Hirohisa; Nakamura, Akira // Inflammation Research;Mar2016, Vol. 65 Issue 3, p235 

    Objectives and design: Hypersensitivity pneumonitis (HP) is a pulmonary disease caused by repeated exposure to various aspiration antigens, including bacteria and fungi. Although TLRs are known to be required for the generation of HP triggered by bacteria, the significance of fungal receptors...

  • CD4+CD25+Foxp3+ Regulatory T Cells Depletion May Attenuate the Development of Silica-Induced Lung Fibrosis in Mice. Fangwei Liu; Jie Liu; Dong Weng; Ying Chen; Laiyu Song; Qincheng He; Jie Chen // PLoS ONE;2010, Vol. 5 Issue 11, p1 

    Background: Silicosis is an occupational lung disease caused by inhalation of silica dust characterized by lung inflammation and fibrosis. Previous study showed that Th1 and Th2 cytokines are involved in silicosis, but Th1/Th2 polarization during the development of silicosis is still a matter of...

  • 16α-Bromoepiandrosterone Restores T Helper Cell Type 1 Activity and Accelerates Chemotherapy-Induced Bacterial Clearance in a Model of Progressive Pulmonary Tuberculosis. Hernãndez-Pando, Rogelio; Aguilar-Leon, Diana; Orozco, Hector; Serrano, Alberto; Ahlem, Clarence; Trauger, Richard; Schramm, Beatrix; Reading, Chris; Frincke, James; Rook, Graham A. W. // Journal of Infectious Diseases;1/15/2005, Vol. 191 Issue 2, p299 

    BALB/c mice with pulmonary tuberculosis develop a T helper cell type 1 response that peaks at 3 weeks, temporarily controlling bacterial growth. Then bacterial proliferation recommences, accompanied by increasing interleukin (IL)-4 levels and decreasing interferon (IFN)-γ, tumor necrosis...

  • The Evolution of Pulmonary Cryptococcosis. Kerkering, Thomas M.; Duma, Richard J.; Shadomy, Smith // Annals of Internal Medicine;May81, Vol. 94 Issue 5, p611 

    Presents a study which examined patients diagnosed as having pulmonary disease caused by Cryptococcus neoformans. Materials and methods used; Analysis of pulmonary diseases of patients; Description of lesions on chest roentgenogram.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics