Folate Intake and Risk of Parkinson’s Disease

Honglei Chen; Zhang, Shumin M.; Schwarzschild, Michael A.; Hernán, Miguel A.; Logroscino, Giancarlo; Willett, Walter C.; Ascherio, Alberto
August 2004
American Journal of Epidemiology;Aug2004, Vol. 160 Issue 4, p368
Academic Journal
In clinical studies, individuals with Parkinson’s disease have had higher concentrations of plasma homocysteine than did controls, and experimental evidence suggests that folate deficiency or focal administration of homocysteine sensitizes dopaminergic neurons to the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The authors thus prospectively investigated whether higher intake of folate, vitamin B6, or vitamin B12 was related to a lower risk of Parkinson’s disease in the Health Professionals Follow-up Study (1986–2000) and the Nurses’ Health Study (1980–1998). They documented Parkinson’s disease diagnoses in 248 men and 167 women during the follow-up. Folate intake was not associated with the risk of Parkinson’s disease; the relative risks for the highest compared with the lowest quintiles were 1.0 (95% confidence interval: 0.7, 1.5) in men and 1.3 (95% confidence interval: 0.8, 2.3) in women. Neither did they find significant associations in analyses stratified by age, smoking, alcohol consumption, or lactose intake. Intake of vitamin B6 or vitamin B12 also was not related to the risk of Parkinson’s disease. The current study does not support the hypothesis that higher intake of folate or related B vitamins lowers the risk of Parkinson’s disease.


Related Articles

  • Homocysteine, Folate and Vitamin B12 Concentrations in Middle Aged Adults Presenting with Sensorineural Hearing Impairment. Gocer, Celil; Genc, Umut; Eryilmaz, Adil; Islam, Ahmet; Boynuegri, Suleyman; Bakira, Fatih // Journal of International Advanced Otology;2009, Vol. 5 Issue 3, p340 

    Objective: Aim of this study was to investigate a possible association between hearing impairment and homocysteine, folate and vitamin B12 concentrations in subjects presenting with sensorineural hearing loss before the geriatric age, namely before the age of 60. Materials and Methods: Pure tone...

  • Prevalence of low serum folate, red cell folate, serum vitamin B12 and elevated homocysteine. Flood, V. M.; Webb, K. L.; Smith, W.; Rochtchina, E.; Mitchell, P. // Asia Pacific Journal of Clinical Nutrition;2004 Supplement, Vol. 13, pS85 

    Background - Recent data indicate that higher risk of cardiovascular disease may result from mild elevation of serum homocysteine, which has been linked to low blood levels of folate and vitamin B12. Folate fortification of food may increase the risk of masking B12 deficiency in older people....

  • Vitamin B12 and Folate Deficiencies and Hyperhomocysteinemia in Elderly. Alshatwi, Ali A. // Journal of Medical Sciences;2007, Vol. 7 Issue 3, p402 

    The object of this study was to evaluate the levels of homocysteine (Hcy) and to evaluate the status of vitamin B12 and folate in elderly males living in the Riyadh city. Notably 34.1 and 88.6% of subjects had vitamin B12 and folate intakes below the DRI, respectively. Mean serum vitamin B12 was...

  • 14. Vitamin B12: 14.6 Criteria for assessing vitamin B12 status.  // Vitamin & Mineral Requirements in Human Nutrition;2004, p283 

    Chapter 14.6 of the book "Vitamin & Mineral Requirements in Human Nutrition" is presented. This section focuses on the criteria for assessing vitamin B12 status. It references a finding which suggested that a proportion of people with normal serum and plasma vitamin B 12 are vitamin B12...

  • How do we evaluate a marginally low B12 level? Cravens, David D.; Nashelsky, Joan // Journal of Family Practice;Jan2007, Vol. 56 Issue 1, p62 

    The article discusses methods of evaluating a marginally low B12 level. Vitamin B12 is a necessary coenzyme in the metabolism of methylmalonic acid to succinylcholine, and is also a necessary coenzyme with folate in the metabolism of homocysteine to methionine. A low-normal B12 level is 150 to...

  • Homocysteine and Cerebral Stroke in Developing Countries. Christopher, Rita; Nagaraja, D.; Shankar, S. K. // Current Medicinal Chemistry;2007, Vol. 14 Issue 22, p2393 

    Two-thirds of stroke deaths worldwide occur in developing countries. The higher prevalence of undernutritional states and parasitic infestations in many of these countries could lead to vitamin B12 and folate deficiencies. Hyperhomocysteinemia, a proxy measure for the nutritional status of B...

  • The Cardiac Effects of Prolonged Vitamin B[sub12] and Folate Deficiency in Rats. Taban-Shomal, Omid; Kilter, Heiko; Wagner, Alexandra; Schorr, Heike; Umanskaya, Natalia; Hübner, Ulrich; Böhm, Michael; Herrmann, Wolfgang; Hermann, Markus // Cardiovascular Toxicology;Summer2009, Vol. 9 Issue 2, p95 

    Abstract In the recent past, hyperhomocysteinemia (HHCY) has been linked to chronic heart failure. Folate and vitamin B12 deficiencies are the common causes of HHCY. The impact of these vitamins on cardiac function and morphology has scarcely been investigated. The aim of this study was to...

  • Discussion: Folate and vitamin B12 metabolism: Overview and interaction with riboflavin, vitamin B6, and polymorphisms. Stover, Patrick // Food & Nutrition Bulletin;Jun2008 Supplement, Vol. 29, pS17 

    The article discusses the significant metabolic relationship of folate and vitamin B12 with its common polymorphisms. It highlights the structures of folic acid and the transport of reduced folate monoglutamates. It also describes the homocysteine and the methionline folate molecule cycles. It...

  • Low Folate Linked to Increased Dementia Risk. Kiefer, Dale // Life Extension;May2008, Vol. 14 Issue 5, p18 

    The article cites a report that connects low folate to increased dementia risk. It is stated that a low baseline level of folate is prognostic of dementia and an amplified decline in folate level is associated with the onset of dementia. In addition, an increase in homocysteine level and a...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics