TITLE

Matrix metalloproteinases in destructive pulmonary pathology

AUTHOR(S)
Elkington, P. T. G.; Friedland, J. S.
PUB. DATE
March 2006
SOURCE
Thorax;Mar2006, Vol. 61 Issue 3, p259
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that have a number of important physiological roles including remodelling of the extracellular matrix, facilitating cell migration, cleaving cytokines, and activating defensins. However, excess MMP activity may lead to tissue destruction. The biology of MMP and the role of these proteases in normal pulmonary immunity are reviewed, and evidence that implicates excess MMP activity in causing matrix breakdown in chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), sarcoidosis, and tuberculosis is discussed. Evidence from both clinical studies and animal models showing that stromal and inflammatory cell MMP expression leads to immunopathology is examined, and the mechanisms by which excess MMP activity may be targeted to improve clinical outcomes are discussed.
ACCESSION #
20349792

 

Related Articles

  • Tenascin-C and alpha-smooth muscle actin positive cells are increased in the large airways in patients with COPD. Löfdahl, Magnus; Kaarteenaho, Riitta; Lappi-Blanco, Elisa; Tornling, Göran; Sköld, Magnus C. // Respiratory Research;Apr2011, Vol. 12 Issue 4, p1 

    Background: Chronic obstructive pulmonary disease (COPD) is characterized by inflammation and remodeling of the lungs. This results in alterations in extracellular matrix (ECM) and structural changes leading to airflow obstruction. We studied the expression of tenascin-C (Tn-C) and alpha smooth...

  • Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma. Matsumoto, H.; Niimi, A.; Takemura, M.; Ueda, T.; Minakuchi, M.; Tabuena, R.; Chin, K.; Mio, T.; Ito, Y.; Muro, S.; Hirai, T.; Morita, S.; Fukuhara, S.; Mishima, M. // Thorax;Apr2005, Vol. 60 Issue 4, p277 

    Background: The balance between matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) may be critical in extracellular matrix remodelling, a characteristic of asthmatic airways. An excess of TIMP-1 over MMP-9 has been associated with chronic airflow obstruction...

  • The Role of Matrix Metalloproteinases in Chronic Pulmonary Diseases: Relevance of the Airway Epithelium. Daheshia, Massoud; Tesfaigzi, Yohannes // Current Respiratory Medicine Reviews;2005, Vol. 1 Issue 2, p165 

    Pulmonary structural changes that lead to decreased airway function are the cardinal features of chronic diseases such as asthma and chronic obstructive pulmonary disease (COPD). Matrix metalloproteinases (MMPs) are a family of zinc-dependent enzymes that can alter lung architecture by inducing...

  • Patients with COPD: do we fail them from beginning to end? Partridge, M.R. // Thorax;May2003, Vol. 58 Issue 5, p373 

    Editorial. Recognizes the burden of chronic obstructive pulmonary disease (COPD) to both the individual and the society. Development of a comprehensive approach for the prevention and control of respiratory disease; Importance of diagnosing COPD early in its natural history.

  • Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study. Mannino, D.M.; Buist, A.S.; Petty, T.L.; Enright, P.L.; Redd, S.C. // Thorax;May2003, Vol. 58 Issue 5, p388 

    Background: A study was undertaken to define the risk of death among a national cohort of US adults both with and without lung disease. Methods: Participants in the first National Health and Nutrition Examination Survey (NHANES I) followed for up to 22 years were studied. Subjects were...

  • Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Brusasco, V.; Hodder, R.; Miravitlles, M.; Korducki, L.; Towse, L.; Kesten, S. // Thorax;May2003, Vol. 58 Issue 5, p399 

    Background: A study was undertaken to record exacerbations and health resource use in patients with COPD during 6 months of treatment with tiotropium, salmeterol, or matching placebos. Methods: Patients with COPD were enrolled in two 6-month randomised, placebo controlled, double blind, double...

  • COPD: Management of Acute Exacerbation and Chronic Stable Disease. Hunter, Melissa H.; King, Dana E. // American Family Physician;8/15/2001, Vol. 64 Issue 4, p603 

    Acute exacerbations of chronic obstructive pulmonary disease (COPD) are treated with oxygen (in hypoxemic patients), inhaled beta2 agonists, inhaled anticholinergics, antibiotics and systemic corticosteroids. Methylxanthine therapy may be considered in patients who do not respond to other...

  • End-stage COPD. Fernandes, Tanya // Nursing Standard;10/10/2012, Vol. 27 Issue 6, p58 

    A quiz on end stage chronic obstructive pulmonary disease is presented.

  • Ultrafine Particles in Human Lung Macrophages. Hauser, Russ; Godleski, John J.; Hatch, Victoria; Christiani, David C. // Archives of Environmental Health;Mar/Apr 2001, Vol. 56 Issue 2, p150 

    ABSTRACT. As knowledge about size dependency of particle toxicity continues to grow, attention has been focused on ultrafine particles (i.e., < 0.1 micro m in diameter). In recent studies with rats, investigators learned that ultrafine particles likely have greater pulmonary toxicity than larger...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics