TITLE

Rapid and simultaneous determination of nonsteroidal anti-inflammatory drugs in human plasma by LC—MS with solid-phase extraction

AUTHOR(S)
Suenami, Koichi; Lee Wah Lim; Takeuchi, Toyohide; Sasajima, Yasuhide; Sato, Kiyohito; Takekoshi, Yuji; Kanno, Susumu
PUB. DATE
April 2006
SOURCE
Analytical & Bioanalytical Chemistry;Apr2006, Vol. 384 Issue 7/8, p1501
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A rapid, selective and sensitive analytical method for the simultaneous determination of 16 nonsteroidal anti-inflammatory drugs (NSAIDs) in human plasma was carried out using Oasis HLB solid-phase extraction (SPE), followed by reversed-phase high-performance liquid chromatography and quadrupole mass spectrometry with electrospray ionization operated in the negative ion mode. The recoveries of NSAIDs from human plasma by SPE were greater than 76.7%. The use of a short column packed with small particles enabled rapid and simultaneous determination within 7 min. The detection limits for the NSAIDs were 0.01–0.9 μg/ml using the selected ion monitoring mode.
ACCESSION #
20329995

 

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