TITLE

Quantitative analysis of Pentalgin tablets by gradient and isocratic high-performance liquid chromatography

AUTHOR(S)
Golubitskii, G.; Budko, E.; Ivanov, V.; Basova, E.
PUB. DATE
April 2006
SOURCE
Journal of Analytical Chemistry;Apr2006, Vol. 61 Issue 4, p350
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The retention of paracetamol, propyphenazone, caffeine, phenobarbital, and codeine phosphate, which are the components of the new medicine Pentalgin, was studied by reversed-phase high-performance liquid chromatography on a column (150 × 3.9 mm) filled with the Symmetry C18 sorbent (5.0 μm) in the gradient elution mode and on a column (150 × 3.9 mm) filled with the Nova-Pak CN HP sorbent (4.0 μm) as a function of the profile and composition of the gradient and as a function of the concentrations of acetonitrile and KH2PO4 and the pH of the mobile phase, respectively, with detection at 212 nm. The optimum composition of the mobile phase was selected. The time of separation was 16 and 11 min for the gradient and isocratic elution modes, respectively. The procedures were used for the analysis of a preproduction sample of the tablets. The procedures provide accurate and reproducible results of analysis; however, the isocratic version is preferable for mass production control as a technically simpler technique.
ACCESSION #
20308871

 

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