COMMENTARY: Review: Saccharomyces boulardii reduces risk for antibiotic-associated diarrhea

Parrino, Thomas A.
March 2006
ACP Journal Club;Mar/Apr2006, Vol. 144 Issue 2, p45
Academic Journal
This article reports that saccharomyces boulardii reduces risk for antibiotic-associated diarrhea. Antibiotic-associated diarrhea (AAD) occurs in up to 30% of patients receiving antibiotics. The most serious form of AAD is mediated by Clostridium difficile associated diarrhea (CDAD). Several antibiotics have been associated with AAD and CDAD. Those with greater potency against anaerobes may predispose to CDAD, which is potentially fatal when it escalates into Clostridium difficile--associated colitis and toxic megacolon. The incidence of CDAD is cyclical. This may relate to variations in antibiotic use, varying community colonization rates, and other factors external to the hospital setting.


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