Drotrecogin-α (activated) did not reduce death and increased bleeding in patients with severe sepsis and low risk for death

March 2006
ACP Journal Club;Mar/Apr2006, Vol. 144 Issue 2, p43
Academic Journal
This article presents a study which revealed that Drotrecogin-α (activated) (DrotAA) did not reduce death and increased bleeding in patients with severe sepsis and low risk for death. The study was conducted on 2640 patients. The patients had to begin treatment within 48 hours of documentation of the first organ dysfunction. All-cause mortality at 28 days. Secondary outcomes were in-hospital mortality within 90 days and adverse events, including bleeding. DrotAA and placebo groups did not differ for mortality at 28 days or for in-hospital mortality within 90 days.


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