Review: Only women with specific family histories should be referred for counseling or evaluation for BRCA breast and ovarian cancer susceptibility

March 2006
ACP Journal Club;Mar/Apr2006, Vol. 144 Issue 2, p37
Academic Journal
This article reports that only women with specific family histories should be referred for counseling or evaluation for BRCA breast and ovarian cancer susceptibility. A primary care approach to screening for inherited breast and ovarian cancer susceptibility has not been evaluated, and evidence is lacking to determine benefits and harms for the general population. Fair evidence exists that women with specific increased-risk family histories are more likely to have BRCA1 or BRCA2 mutations associated with breast and ovarian cancer. About 2% of women in the general population have such a family history.


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