Review: Lorazepam provides the best control for status epilepticus

March 2006
ACP Journal Club;Mar/Apr2006, Vol. 144 Issue 2, p35
Academic Journal
The article focuses on a study which reveals that lorazepam provides the best control for status epilepticus (SE). Randomized or quasi-randomized controlled trials were conducted that compared any anticonvulsant drug with placebo or another anticonvulsant drug in patients with premonitory, early stage, established or refractory SE. Superior results were seen with intravenous (IV) lorazepam for cessation of seizures and reducing risk for SE that required a second drug. IV diazepam was better than placebo for reducing death, continuation of seizures, SE and ventilatory support.


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