TITLE

Hepatitis C: a review for primary care physicians

AUTHOR(S)
Wong, Tom; Lee, Samuel S.
PUB. DATE
February 2006
SOURCE
CMAJ: Canadian Medical Association Journal;2/28/2006, Vol. 174 Issue 5, p649
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract Primary care physicians see many of the estimated 250 000 Canadians chronically infected with the hepatitis C virus (HCV). Of this number, about one-third are unaware they are infected, which constitutes a large hidden epidemic. They continue to spread HCV unknowingly and cannot benefit from advances in antiviral therapy that may clear them of the virus. Many HCV-infected people remain asymptomatic, which means it is important to assess for risk factors and test patients accordingly. The third-generation enzyme immunoassay for HCV antibodies is a sensitive and specific test, although the presence of the virus can be confirmed by polymerase chain reaction testing for HCV RNA in some circumstances. Pegylated interferon-α and ribavirin combination therapy clears the virus in about 45%-80% of patients, depending on viral genotype. Preventive strategies and counselling recommendations are also reviewed.
ACCESSION #
20256880

 

Related Articles

  • Acute Posttransfusion Hepatitis C: Identification of a Common Hepatitis C Virus Strain in Donor and Recipient Using Polymorphism Analysis. Chinchai, T.; Noppornpanth, S.; Theamboonlers, A.; Chongsrisawat, V.; Poovorawan, V. // Infection;Feb2001, Vol. 29 Issue 1, p40 

    An 11-year-old Thai boy who had received multiple blood transfusions from 12 different donors for treatment of Dengue shock syndrome presented with symptoms of acute hepatitis 5 weeks thereafter. He was found positive for antibodies to hepatitis C virus (HCV) and HCV-RNA was detected by reverse...

  • Hepatitis C Virus Replicates in the Liver of Patients Who Have a Sustained Response to Antiviral Treatment. Castillo, Inmaculada; Rodríguez-Iñigo, Elena; López-Alcorocho, Juan Manuel; Pardo, Margarita; Bartolomé, Javier; Carreño, Vicente // Clinical Infectious Diseases;11/15/2006, Vol. 43 Issue 10, p1277 

    Background. Positive-strand hepatitis C virus (HCV) RNA has been detected in the livers of patients who have achieved a sustained biochemical and virological response to antiviral therapy (hereafter, referred to as sustained responders), but negative-strand HCV RNA was undetectable in the...

  • Antiviral Genetic Program Is a New Type of DNA Vaccine. Sivov, I. G.; Sobolev, A. Yu.; Samokhvalov, E. I.; Sergienko, V. I. // Doklady Biochemistry & Biophysics;Mar/Apr2001, Vol. 377 Issue 1-6, p137 

    Discusses a research on an antiviral genetic program that is identified as a type of DNA vaccine. Factors that contribute to chronic hepatitis C virus (HCV); Isolation of genomic HCV RNA from the sera of patients with hepatitis C; DNA and RNA used in polymerase chain reaction.

  • Sensitivity of a Ribavirin Resistant Mutant of Hepatitis C Virus to Other Antiviral Drugs. Mihalik, Kathleen B.; Feigelstock, Dino A. // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1 

    Background: While ribavirin mono-therapy regimens have minimal effect on patients with chronic hepatitis C virus (HCV) infections, they can be efficacious when combined with interferon. Clinical studies show that interferon-free combination therapies containing ribavirin are also efficacious,...

  • TT Virus Infection in Patients with Hepatitis C: Frequency, Persistence, and Sequence Heterogeneity. Irving, William L.; Ball, Jonathan K.; Berridge, Selina; Curran, Rebecca; Grabowska, Anna M.; Jameson, Claire L.; Neal, Keith R.; Ryder, Steven D.; Thomson, Brian J. // Journal of Infectious Diseases;7/1/99, Vol. 180 Issue 1, p27 

    Studies the role of the TT virus (TTV) in hepatitis C. Use of polymerase chain reaction protocols to detect TTV DNA; Difference in the severity of hepatitis C in persons coinfected with TTV and hepatitis C virus (HCV) compared with those infected with HCV alone; Persistence of TTV DNA in serum...

  • Hepatitis C Virus Not Found in Fulminant Non-A, Non-B Hepatitis. Wright, Teresa L.; Hsu, Henry; Donegan, Elizabeth; Feinstone, Stephen; Greenberg, Harry; Read, Alexandra; Ascher, Nancy L.; Roberts, John P.; Lake, John R. // Annals of Internal Medicine;7/15/91, Vol. 115 Issue 2, p111 

    Focuses on the use of a sensitive and specific polymerase chain reaction to detect hepatitis C virus (HCV) ribonucleic acid (RNA) in patients with fulminant hepatic failure of unknown cause. Factor that influenced the need to use the chain reaction; Method for analyzing polymerase chain...

  • How Stable Is the Hepatitis C Virus (HCV)? Environmental Stability of HCV and Its Susceptibility to Chemical Biocides. Ciesek, Sandra; Friesland, Martina; Steinmann, Jörg; Becker, Britta; Wedemeyer, Heiner; Manns, Michael P.; Steinmann, Jochen; Pietschmann, Thomas; Steinmann, Eike // Journal of Infectious Diseases;6/15/2010, Vol. 201 Issue 12, p1859 

    Background. In the absence of a cell culture system for propagation of the hepatitis C virus (HCV), the antiviral activity of disinfectants against HCV was extrapolated from studies with the bovine viral diarrhea virus. The recent development of an HCV infection system allowed the direct...

  • Correction.  // Gut;Aug2012, Vol. 61 Issue 8, p1145 

    A correction to the article "New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectives," that was published in the previous issue of the journal is presented.

  • Analytical variables influencing the HCV RNA determination by TaqMan real-time PCR in routine clinical laboratory practice. Raza, Abida; Ali, Zameer; Irfan, Javaid; Murtaza, Shahnaz; Shakeel, Samina // Molecular Biology Reports;Jul2012, Vol. 39 Issue 7, p7421 

    Hepatitis C virus (HCV) quantification is used as a prognostic marker for treatment success. In a routine clinical laboratory some infinitesimal sample handling factors can contribute to variability and loss of precision in HCV quantification. This may include blood collection tubes, blood...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics