Rosiglitazone (Avandia) and macular edema

Kendall, Claire
February 2006
CMAJ: Canadian Medical Association Journal;2/28/2006, Vol. 174 Issue 5, p623
Academic Journal
The article focuses on the occurrence of macular edema in patients taking thiazolidinediones such as rosiglitazone in the treatment of type two diabetes and polycystic ovarian disease. Macular edema is caused by blood vessels that leak plasma into the surrounding retina. Thiazolidinediones are hypothesized to cause peripheral edema by affecting renal and intestinal ion transport, increasing plasma volume and sympathetic activation and causing growth factor-related vascular permeability.


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