TITLE

Family history of gastric cancer: a correlation between epidemiologic findings and clinical data

AUTHOR(S)
Bernini, Marco; Barbi, Stefano; Roviello, Franco; Scarpa, Aldo; Moore, Patrick; Pedrazzani, Corrado; Beghelli, Stefania; Marrelli, Daniele; de Manzoni, Giovanni
PUB. DATE
March 2006
SOURCE
Gastric Cancer;Mar2006, Vol. 9 Issue 1, p9
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. The pathogenetic mechanisms behind gastric cancer are still unclear. Its familial aggregation, on the other hand, has been very well documented by many epidemiologists. Nonetheless, only a limited number of studies have analyzed possible correlations between demographic and clinical data. Methods. Between January 1988 and August 2004, 541 patients underwent gastric resection with a curative intent at our department; demographic information, laboratory data, imaging, operative notes, and pathology reports were available for all patients. During 2004 we conducted a series of structured interviews with the surviving patients or their closest relatives regarding oncological family history, limited to firstdegree relatives. Results. Family history could be obtained in 383 patients (70.8%). Gastric cancer was by far the most frequently associated tumor: 21.9% of the overall number of tumors reported in the family histories were gastric cancers. Patients were also subdivided into those having at least one other family member with stomach cancer (71 patients; 18.5%) and those with no relatives affected by gastric cancer (312 patients; 81.5%). No statistically significant differences between the groups were observed regarding the primary tumor location, size, pTNM classification, and ABO or Rh blood types. However, the intestinal histotype was significantly (P = 0.015) more frequently represented in individuals with at least one family member affected by gastric cancer compared with those with no relatives with stomach cancer (71.8% vs 55.1%, respectively). Conclusions. Stomach cancer has a relevant degree of familial aggregation and in our series of patients, this was even more pronounced for the intestinal histotype.
ACCESSION #
20239674

 

Related Articles

  • Predictors of long-term survival in node-positive gastric carcinoma patients with curative resection. Dong Yi Kim; Jae Kyoon Joo; Young Kyu Park; Seong Yeob Ryu; Young Jin Kim; Shin Kon Kim // Langenbeck's Archives of Surgery;Apr2007, Vol. 392 Issue 2, p131 

    We analyzed the clinicopathologic features of node-positive gastric carcinoma patients who were long-term survivors (5 years or longer) and evaluated the predictive factors associated with long-term survival. Of 554 node-positive gastric carcinoma patients with curative resection, 161 (29.1%)...

  • Different Sites and Prognoses of Gastrointestinal Stromal Tumors of the Stomach: Report of 187 Cases. Hai Huang; Yan-Xue Liu; Zhong-Li Zhan; Han Liang; Pu Wang; Xiu-Bao Ren // World Journal of Surgery;Jul2010, Vol. 34 Issue 7, p1523 

    The stomach is the most common site of gastrointestinal stromal tumors (GISTs), but the clinical behavior of gastric GISTs at different sites is unclear. This study was designed to evaluate the clinicopathological (CP) parameters and influence of different gastric sites on outcome in patients...

  • Influence of a Positive Proximal Margin on Oral Intake in Patients with Palliative Gastrectomy for Far Advanced Gastric Cancer. Tanizawa, Yutaka; Bando, Etsuro; Kawamura, Taiichi; Tokunaga, Masanori; Kondo, Junya; Taki, Yusuke; Terashima, Masanori // World Journal of Surgery;May2011, Vol. 35 Issue 5, p1030 

    Background: Resection margin involvement is one of the most significant risk factors for local recurrence in curative gastrectomy, and local recurrence results in anastomotic stenosis. In the present study, the effects of a positive resection margin in palliative gastrectomy on the symptoms of...

  • Outcome of endoscopic submucosal dissection for gastric neoplasm in relationship to endoscopic classification of submucosal fibrosis. Higashimaya, Makoto; Oka, Shiro; Tanaka, Shinji; Sanomura, Yoji; Yoshida, Shigeto; Hiyama, Toru; Arihiro, Koji; Shimamoto, Fumio; Chayama, Kazuaki // Gastric Cancer;Jul2013, Vol. 16 Issue 3, p404 

    Background: Whether submucosal fibrosis is related to ulceration and affects the outcome of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is unknown. This study aimed to determine ESD outcome in relationship to degree of submucosal fibrosis of gastric epithelial neoplasms...

  • Aggressive surgical treatment for T4 gastric cancer Kobayashi, Akihiko; Nakagohri, Toshio; Konishi, Masaru; Inoue, Kazuto; Takahashi, Shinichirou; Itou, Masaaki; Sugitou, Masanori; Ono, Masato; Saito, Norio; Kinoshita, Taira // Journal of Gastrointestinal Surgery;May2004, Vol. 8 Issue 4, p464 

    Surgical treatment for locally advanced gastric cancer remains controversial, and many still question the benefits of extended resection. The aim of this study was to evaluate the effectiveness of combined resection of the involved organs with regard to survival in patients with gastric cancer....

  • Impact of Clinical and Pathohistological Characteristics on the Incidence of Recurrence and Survival in Elderly Patients with Gastric Cancer. Dittmar, Yves; Rauchfuss, Falk; Götz, Max; Scheuerlein, Hubert; Jandt, Karin; Settmacher, Utz // World Journal of Surgery;Feb2012, Vol. 36 Issue 2, p338 

    Background: Gastric cancer is one of the most frequent malignant tumors worldwide. Despite improvements in diagnostic procedures, as well as the introduction of multimodal treatment strategies, the overall prognosis remains poor. The role of gastric resection in elderly patients with gastric...

  • Gastric Cancer: A New Endoscopic Management Option. Niwa, Yasumasa; Kobayashi, Seibi; Johnson, David // American Journal of Gastroenterology;May1999, Vol. 94 Issue 5, p1413 

    Presents a study which examined the effectiveness of aspiration endoscopic mucosal resection (EMR) in the management of early gastric cancer in the C and M regions of the stomach. Rate of complete resection in the EMR-1CS and 2CS groups of patients; Main advantage of the aspiration method;...

  • Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for advanced gastric cancer Hall, Jason J.; Loggie, Brian W.; Shen, Perry; Beamer, Staci; Douglas Case, L.; McQuellon, Richard; Geisinger, Kim R.; Levine, Edward A. // Journal of Gastrointestinal Surgery;May2004, Vol. 8 Issue 4, p454 

    Peritoneal carcinomatosis is a common and universally fatal sequelae of gastric carcinoma. Treatment of peritoneal carcinomatosis from appendiceal and colorectal sources with intraperitoneal hyperthermic chemotherapy (IPHC) combined with aggressive cytoreductive surgery has been shown to be...

  • Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a retrospective comparison with conventional endoscopic resection in a single center. Tanabe, Satoshi; Ishido, Kenji; Higuchi, Katsuhiko; Sasaki, Tohru; Katada, Chikatoshi; Azuma, Mizutomo; Naruke, Akira; Kim, Myungchul; Koizumi, Wasaburo // Gastric Cancer;Jan2014, Vol. 17 Issue 1, p130 

    Background: Few studies have compared the outcomes of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in patients with early gastric cancer. Methods: We studied 780 lesions for which endoscopic treatment was indicated according to the Japanese Gastric Cancer...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics