Incidence of a Type AB Infant Born to a Type O Mother

Christina P. Nickel
January 2006
Laboratory Medicine;Jan2006, Vol. 37 Issue 1, p37
Academic Journal
Routine cord blood testing may include ABO, Rh, Direct Antigen Testing (DAT) and Indirect Coombs testing (IDC), among other testing, but varies widely from blood bank to blood bank. In this case, the routine testing revealed that an AB infant was born to an O mother. It is not routine to find an AB infant born to an O mother, as the mother carries an O,O type and would have to pass an O to the infant, leaving the possibilities of O,O; A,O; or B,O type for the infant, depending on the father's blood type. Because of the rarity of an AB infant being born to an O mother, several troubleshooting steps were taken prior to the release of test results. It is important to investigate whenever there is a discrepancy discovered during laboratory testing. An AB and O couple producing an AB child cannot be explained in terms of the usual inheritance patterns. One would not expect the cord blood result to be AB when the mother is type O, however, in very rare instances, such as the cis-AB blood type, it is possible. Extensive troubleshooting revealed the infant to have this very rare cis-AB blood type.


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