Slipping the barrier: how variants in CARD 15 could alter permeability of the intestinal wall and population health

Schreiber, S.
March 2006
Gut;Mar2006, Vol. 55 Issue 3, p308
Academic Journal
The increased intestinal permeability in Crohn's disease is associated with the presence of variants in the CARD15 gene that are regarded as causative for Crohn's disease, suggesting a genetic rather than an environmental background for intestinal Barrier dysfunction in Crohn's disease.


Related Articles

  • Role of interleukin 6 in a murine model of Crohn's ileitis: are cytokine/anticytokine strategies the future for IBD therapies? Pizarro, T. T.; de la Rue, S. A.; Cominelli, F. // Gut;Sep2006, Vol. 55 Issue 9, p1226 

    The article focuses on the significance of interleukin 6 (IL-6) in Crohn's ileitis in the murine model SAMP/Yit. Research revealed that administration of hyper IL-6 increased the severity of the disease in the mice. On the other hand, treatment with an inhibitor of IL-6 improves the severity of...

  • Pneumaturia as a Presenting Sign of Regional Enteritis. Peck, Owen C.; Babb, Richard R. // American Journal of Gastroenterology;Nov1971, Vol. 56 Issue 5, p463 

    Describes the case of a patient who was hospitalized with abdominal pain and found to have an ileovesical fistula secondary to regional enteritis. Presenting symptom of regional enteritis; Urologic manifestations of the disease; Overall incidence of the disorder; Result of the patient's...

  • The Relationship Between Heritability and Smoking Habits in Crohn's Disease. Brignola, Corrado; Belloli, Clarissa; Ardizzone, Sandro; Astegiano, Marco; Cottone, Mario; Trallori, Giacomo // American Journal of Gastroenterology;Nov2000, Vol. 95 Issue 11, p3171 

    OBJECTIVE: In Crohn's disease (CD), the relationship between genetic predisposition and smoking has not been well defined. The aim of this study was to compare the smoking habits at the time of the diagnosis of CD patients having familial occurrence of inflammatory bowel disease (IBD) with those...

  • REGIONAL ENTERITIS. Berger, Samuel S. // American Journal of Gastroenterology;Jul1956, Vol. 26 Issue 1, p81 

    Presents a case of a patient with regional enteritis. Persistence of abdominal pains suffered by the patient; Examination of the abdomen of the patient; Pathology of the regional enteritis.

  • Pneumatosis Cystoides Intestinalis with Free Intraperitoneal Air: A Case Report. Hwang, Joanna; Reddy, V. Sreenath; Sharp, Kenneth W. // American Surgeon; 

    Pneumatosis cystoides intestinalis (PCI) is a rare disorder of the medical management and clinical outcome of which largely depend on the severity of its clinical manifestation. A limited number of cases have been reported in the literature although it is suggested that the true incidence of...

  • Free Perforation in Crohn's Disease: I. A Survey of 99 Cases. Greenstein, A. J.; Mann, D.; Sachar, D. B.; Aufses Jr., A. H. // American Journal of Gastroenterology;Sep1985, Vol. 80 Issue 9, p682 

    A review of more than 181 reported cases of free perforation in Crohn's disease yielded 84 cases that fulfilled rigorous criteria for classification as spontaneous free perforation with generalized peritonitis. An additional 15 cases from The Mount Sinai Hospital, derived from a population of...

  • Anastomotic Configuration and Mucosal 5-Aminosalicylic Acid (5-ASA) Concentrations in Patients With Crohn's Disease: A GISC Study. Frieri, Giuseppe; Pimpo, M. T.; Palumbo, G.; Tonelli, F.; Annese, V.; Sturniolo, G. C.; Andreoli, A.; Comberlato, M.; Corrao, G.; Caprilli, R. // American Journal of Gastroenterology;Jun2000, Vol. 95 Issue 6, p1486 

    OBJECTIVE: Recurrence of Crohn's disease quite inevitably occurs after resection of distal small bowel and proximal colon, involving the neoterminal ileum close to the anastomosis. Oral 5-aminosalicylic acid (5-ASA) administered soon after surgery delays recurrence and reduces its severity. We...

  • Granulomatous Enterocolitis Complicated by Osteomyelitis. Meltzer, Saul S. // American Journal of Gastroenterology;Jan1973, Vol. 59 Issue 1, p77 

    Osteomyelitis complicating granulomatous disease of the bowel is described in a case report. Bony complications of this disorder should be kept in mind since they may occur more commonly than has previously been appreciated.

  • Regional Enteritis and its Relation to Emotional Disorders. Cohn, Edwin M.; Lederman, Ivan I.; Shore, Eugene // American Journal of Gastroenterology;Oct1970, Vol. 54 Issue 4, p378 

    A clinical investigation was carried out to determine the relationship between emotional traits and regional enteritis. Each patient in whom the diagnosis of ileitis was firmly established, was interviewed psychiatrically and was examined by a psychologist employing standard testing procedures....


Read the Article


Sign out of this library

Other Topics