B Cells in Health and Disease
- Intravenous immunoglobulin up-regulates the expression of the inhibitory FcÎ³IIB receptor on B cells. Nikolova, Kalina A.; Tchorbanov, Andrey I.; Djoumerska-Alexieva, Iglika K.; Nikolova, Maria; Vassilev, Tchavdar L. // Immunology & Cell Biology;Oct2009, Vol. 87 Issue 7, p529
Intravenous immunoglobulin (IVIg) preparations are known to modulate autoimmune/inflammatory diseases through several F(ab')2- and Fc-dependent mechanisms. In this study, we show that the in vitro and the in vivo exposure of B lymphocytes from lupus-prone and from healthy mice to IVIg results in...
- New Regulator Plays Critical Role in Development B Cells. // Trends in Medical Research;2011, Vol. 6 Issue 3, p215
No abstract available.
- Outstanding Merit Award for 2013. // International Immunology;Jul2014, Vol. 26 Issue 7, p355
No abstract available.
- The Major Players in Adaptive Immunity. Ahmed, Asma; Saha, Banishree; Patwardhan, Anand; Shivaprasad, Shwetha; Nandi, Dipankar // Resonance: Journal of Science Education;Jun2009, Vol. 14 Issue 6, p610
Our immune system, by and large, does a fine job in protecting us from opportunistic and infectious microbes, potential carcinogens and allergens. It is therefore crucial to understand the organization of the immune network. This article focuses on some important features and key players...
- Research highlights. // Nature;1/6/2005, Vol. 433 Issue 7021, p29
This article reports on various scientific research. One of them is the research on B cells. Researchers investigated whether defective reaction involves an age-related problem with the antibody-producing B cells, or with the T cells that help them out. When the authors transferred aged helper T...
- New frontiers of primary antibody deficiencies. Burg, Mirjam; Zelm, Menno; Driessen, Gertjan; Dongen, Jacques // Cellular & Molecular Life Sciences;Jan2012, Vol. 69 Issue 1, p59
Primary antibody deficiencies (PAD) form the largest group of inherited disorders of the immune system. They are characterized by a marked reduction or absence of serum immunoglobulins (Ig) due to disturbed B cell differentiation and by a poor response to vaccination. PAD can be divided into...
- Uptake and Presentation of Myelin Basic Protein by Normal Human B Cells. Brimnes, Marie Klinge; Hansen, Bjarke Endel; Nielsen, Leif Kofoed; Dziegiel, Morten Hanefeld; Nielsen, Claus Henrik // PLoS ONE;Nov2014, Vol. 9 Issue 11, p1
B cells may play both pathogenic and protective roles in T-cell mediated autoimmune diseases such as multiple sclerosis (MS). These functions relate to the ability of B cells to bind and present antigens. Under serum-free conditions we observed that 3â€“4% of circulating B cells from...
- What is missing in immunology to understand immunity? Zinkernagel, Rolf M. // Nature Immunology;Sep2000, Vol. 1 Issue 3, p181
Analyzes immune responses from an evolutionary point of view. Primary function of the immune system; Gaussian-type distribution of immune reactivity; Specificity of immune responses; Role of B cells in immune responses.
- The significance of natural autoantibodies. Cojocaru, M.; Cojocaru, Inimioara Mihaela; Silosi, Isabela // Maedica - a Journal of Clinical Medicine;2009, Vol. 4 Issue 1, p22
Autoimmune disease is a disorder that occurs because of autoimmunity. Natural autoantibodies (NAb) are an important component of the normal immune system, and B cells with these self specificities appear to be positively selected during development. There is autoimmunity without autoimmune...