TITLE

Anticipating Potential Linezolid-SSRI Interactions in the General Hospital Setting: An MAOI in Disguise

AUTHOR(S)
Sola, Christopher L.; Bostwick, Michael; Hart, Dionne A.; Lineberry, Timothy W.
PUB. DATE
March 2006
SOURCE
Mayo Clinic Proceedings;Mar2006, Vol. 81 Issue 3, p330
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Linezolid, a novel antimicrobial with activity against gram-positive bacteria including pathogens resistant to traditional antimicrobials, also inhibits monoamine oxidase. This latter property can cause potentially lethal adverse interactions with antidepressant medications. Long known to psychiatrists, monoamine oxidase inhibitors (MAOIs) and complications of their use may be unfamiliar to medical and surgical practitioners who may thus unwittingly precipitate a hypertensive crisis or serotonin syndrome. We review the pharmacology of MAOIs and describe 3 clinical situations in which linezolid—selective serotonin inhibitor (SSRI) interactions, actual or potential, figured prominently.
ACCESSION #
20081109

 

Related Articles

  • Evaluation of Antimicrobial Efficacy of Flavonoids of Withania Somnifera L. Singh, G.; Kumar, P. // Indian Journal of Pharmaceutical Sciences;Jul/Aug2011, Vol. 73 Issue 4, p473 

    In the present study antimicrobial activity of Withania somnifera L. Dunal (Solanaceae) has been evaluated against selected pathogens. Free and bound lavonoids of different parts (root, stem, leaf and fruit) of W. somnifera have been studied for their antimicrobial activity using disc diffusion...

  • Recovery and Detection of Microbial Contaminants in Some Non-Sterile Pharmaceutical Products. El-Houssieny, Rania Saeed; Aboulwafa, Mohammad Mabrouk; Elkhatib, Walid Faisal; Hassouna, Nadia Abdel-Haleim // Archives of Clinical Microbiology;2013, Vol. 4 Issue 6, p1 

    Background: The presence of microbial contaminants in non-sterile pharmaceutical preparations was not only found to cause spoilage of numerous products but was also proved to be a potential health hazard to the consumer. Accordingly, non-sterile preparations have to pass microbial bioburden...

  • The Interaction Pattern of Murine Serum Ficolin-A with Microorganisms. Hummelshøj, Tina; Ying Jie Ma; Lea Munthe-Fog; Bjarnsholt, Thomas; Moser, Claus; Skjoedt, Mikkel-Ole; Romani, Luigina; Fujita, Teizo; Endo, Yuichi; Garred, Peter // PLoS ONE;May2012, Vol. 7 Issue 5, p1 

    The ficolins are soluble pattern recognition molecules in the lectin pathway of complement, but the spectrum and mode of interaction with pathogens are largely unknown. In this study, we investigated the binding properties of the murine serum ficolin-A towards a panel of different clinical...

  • Linezolid, Critical Characteristics. Hamel, J. C.; Stapert, D.; Moerman, J. K.; Ford, C. W. // Infection;Feb2000, Vol. 28 Issue 1, p60 

    In spite of a constantly expanding information base with the oxazolidinones generally and linezolid specifically, we have elected here to focus on the key characteristics of linezolid. Linezolid is the first member of a new class of antimicrobial agents, the oxazolidinones, to be tested in...

  • Antimicrobial Activities of 7-Aminosterol Squalamine Analogues. Loncle, Celine; Salmi, Chanaz; Vidal, Nicolas; Letourneux, Yves; Brunel, Jean Michel // Letters in Drug Design & Discovery;Sep2008, Vol. 5 Issue 6, p388 

    A series of new 7-aminosteroid derivatives were evaluated for their in vitro antimicrobial properties against human pathogens such as Gram positive bacteria. All the compounds present excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and...

  • Comparative In Vitro Surveillance of Amoxicillin-Clavulanic Acid and Four Oral Comparators Against 21,232 Clinical Isolates from Europe. Hoban, D. J.; Bouchillon, S. K.; Johnson, J. L.; Zhanel, G. G.; Butler, D. L.; Saunders, K. A.; Miller, L. A.; Poupard, J. A. // European Journal of Clinical Microbiology & Infectious Diseases;Apr2003, Vol. 22 Issue 4, p261 

    The present study was conducted to determine the in vitro activity of amoxicillin-clavulanic acid compared to that of four newer antimicrobial agents (ampicillin, azithromycin, cefuroxime and trimethoprim-sulfamethoxazole). All of the agents were tested against 21,232 recent clinical isolates...

  • Biological Investigation of Macrotyloma uniflorum Linn. Extracts Against Some Pathogens. Kawsar, S. M. A.; Uddin, M. Seraj; Huq, E.; Nahar, N.; Ozeki, Yasuhiro // Journal of Biological Sciences;2008, Vol. 8 Issue 6, p1051 

    In the present research, attempt was taken to explore the antimicrobial potency of the crude extracts of the Macrotyloma uniflorum plant. The extractives of the plant were subjected to screening for inhibition of microbial growth by the disc diffusion method. The zones of inhibition demonstrated...

  • Assessment of antimicrobial activity of coffee brewed in three different ways from different origins. Martínez-Tomé, Magdalena; Jiménez-Monreal, Antonia; García-Jiménez, Laura; Almela, Luis; García-Diz, Luis; Mariscal-Arcas, Miguel; Murcia, M. // European Food Research & Technology;Sep2011, Vol. 233 Issue 3, p497 

    The antimicrobial effect against pathogens such as Staphylococcus aureus, Enterecoccus faecalis, Listeria monocytogenes, Pseudomonas aeruginosa, Escherichia coli and Salmonella choleraesius was determined in four types of coffee ( Coffea arabica L. cv. Colombia, decaffeinated cv. Colombia, cv....

  • Antimicrobial Activity of Different Aqueous Lemon Extracts. Hindi, Nada Khazal Kadhim; Chabuck, Zainab Adil Ghani // Journal of Applied Pharmaceutical Science;Jun2013, Vol. 3 Issue 6, p74 

    Over three-quarter of the world's population is using herbal medicines with an increasing trend globally. Plant medicines may be beneficial but are not completely harmless. The aim of this study is to evaluate the antimicrobial activity of different types and part of lemon against different...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics