Herpes simplex keratitis and visual impairment: A case series

Kabra, Amit; Lalitha, Prajna; Mahadevan, Kannan; Prajna, Namperumalsamy Venkatesh; Srinivasan, Muthaiah
March 2006
Indian Journal of Ophthalmology;Mar2006, Vol. 54 Issue 1, p23
Academic Journal
Purpose: To record the natural history of herpes simplex keratitis and estimate visual impairment in eyes of patients diagnosed with herpes simplex keratitis Materials: This was a retrospective, descriptive case study for five years of the eyes of patients with clinically diagnosed herpes simplex keratitis. These patients had presented to the cornea services and a cornea specialist carried out the ocular examination under slit-lamp magnification. The medical records were reviewed by the authors. Visual acuity at presentation and clinical details on examination were recorded and, diagnosis of the stage of disease given in the case record was noted. Statistical analysis was done using chi-square-test and Fisher exact test. Results: Of a total of 212 patients (220 eyes), there were 144 males and 68 females; 118 eyes presented with stromal lesions, 44 eyes with epithelial lesions, 39 eyes with epithelial and stromal lesions, and 19 eyes with endothelitis. The improvement in visual acuity to more than 20/40 in the four clinical groups was 23 out of 44 eyes with epithelial lesion (52.27%), 83 out of the 118 eyes with stromal lesions (70.33%), 23 out of 39 eyes with epithelial and stromal lesions (58.97%), and 8 out of the 19 eyes with endothelitis (42.10%). The mean improvement in visual acuity was 3.44 lines (SD ± 4.06). Conclusion: Most patients had mild disease. The majority of the patients attained the final visual acuity of 6/12 or better in the affected eye. Thus, there was only a temporary visual morbidity with fairly good functional visual outcome in majority of the patients.


Related Articles

  • Recurrence of bilateral herpes simplex virus keratitis following bimatoprost use. Kothari, Mihir Trilok; Mehta, Bijal Kabir; Asher, Neetu Sandeep; Kothari, Kulin Jayantilal // Indian Journal of Ophthalmology;Mar2006, Vol. 54 Issue 1, p47 

    A 76-year-old man presented with features of bilateral herpes simplex virus (HSV) keratitis. It was found to be recurrence of bilateral HSV keratitis following the use of Bimatoprost eye drops for uncontrolled intraocular pressure in a case of bilateral primary open-angle glaucoma.

  • The role of common viral ocular pathogens in Thygeson's superficial punctate keratitis. Connell, Paul P.; O'Reilly, James; Coughlan, Suzie; Collum, Louis M. T.; Power, William J. // British Journal of Ophthalmology;Aug2007, Vol. 91 Issue 8, p1038 

    Background/aims: The aetiology of Thygeson's superficial punctate keratitis (TSPK) remains elusive. A viral aetiology has been suggested by the absence of bacterial infection and clinical resemblance to other viral keratopathies. We report the results of polymerase chain reaction analysis for...

  • Detection of ICP0 protein in tear fluid of individuals with active herpetic epithelial keratitis. Morishige, Naoyuki; Yamada, Naoyuki; Morita, Yukiko; Nakamura, Yoshikuni; Nishida, Teruo; Sonoda, Koh-Hei // Japanese Journal of Ophthalmology;Nov2011, Vol. 55 Issue 6, p591 

    Purpose: Infected cell protein 0 (ICP0) has been detected in the tear fluid of rabbits with herpetic keratitis. Here, we investigated whether ICP0 of herpes simplex virus 1 is detectable in the tear fluid of patients with herpetic epithelial keratitis. Methods: Seven patients with herpetic...

  • HERPES SIMPLEX KERATITIS. Fraser, Scott // Pulse;7/9/2008, Vol. 68 Issue 24, p37 

    The article offers information on herpes simplex keratitis (HSK). Herpes simplex virus infections of the cornea causes a profound impairment of vision in the affected eye due to corneal scarring. It states that prolonged inflammation associated with HSK can also cause cataract and glaucoma. It...

  • Herpes Simplex Virus Type 1 DNA in Human Corneas: What Are the Virological and Clinical Implications? Hill, James M.; Clement, Christian // Journal of Infectious Diseases;7/1/2009, Vol. 200 Issue 1, p1 

    The article presents the authors' perspective on a study about the prevalence of herpes simplex virus type 1 (HSV-1) DNA in human cornea tissues, published within the issue. They contend that the study provides additional knowledge about (HSV-1) DNA and offers important clinical information...

  • Acyclovir-Resistant Corneal HSV-1 Isolates from Patients with Herpetic Keratitis. Duan, Rui; de Vries, Rory D.; Osterhaus, Albert D. M. E.; Remeijer, Lies; Verjans, Georges M. G. M. // Journal of Infectious Diseases;9/1/2008, Vol. 198 Issue 5, p659 

    The prevalence and molecular characteristics of isolates from 173 immunocompetent patients with herpetic keratitis (HK) who were infected with acyclovir (ACV)-resistant(ACVR) corneal herpes simplex virus (HSV)-1 was determined. Isolates from 11 (6.4%) of the patients were ACVR, and 9 of these 11...

  • Topical ganciclovir safe, effective for herpes keratitis. Taisma, Julia // Ophthalmology Times;3/1/2005, Vol. 30 Issue 5, p41 

    The article reports on a safe and effective treatment for herpes keratitis. Ganciclovir 0.15% gel is a safe treatment for herpes keratitis, the most common cause of corneal blindness as well as the third most common indication for corneal transplantation, reported researcher Khalid F. Tabbara...

  • A little sore. Newnham, David // Nursing Standard;11/2/2011, Vol. 26 Issue 9, p27 

    David Newnham dreads that tell-tale tingle.

  • Pathogenesis and management of herpes simplex virus keratitis. Tullo, A. // Eye;Nov2003, Vol. 17 Issue 8, p919 

    Herpes simplex keratitis (HSK) remains a common cause of unilateral corneal disease. Despite intense research over three decades, the mainstay of therapy continues to be topical and, more recently, systemic acyclovir plus topical corticosteroid in some cases. There is increasing recognition that...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics