Comparison of an Anti-Rabies Human Monoclonal Antibody Combination with Human Polyclonal Anti-Rabies Immune Globulin

Goudsmit, Jaap; Marissen, Wilfred E.; Weldon, William C.; Niezgoda, Michael; Hanlon, Cathleen A.; Rice, Amy B.; de Kruif, John; Dietzschold, Bernhard; Bakker, Alexander B. H.; Rupprecht, Charles E.
March 2006
Journal of Infectious Diseases;3/15/2006, Vol. 193 Issue 6, p796
Academic Journal
The World Health Organization estimates human mortality from endemic canine rabies to be 55,000 deaths/ year. Limited supply hampers the accessibility of appropriate lifesaving treatment, particularly in areas where rabies is endemic. Anti-rabies antibodies are key to protection against lethal rabies. Currently, only human and equine polyclonal anti-rabies immune globulin (HRIG and ERIG) is available. Replacement of HRIG and ERIG with a safer and more widely available product is recommended. We have recently identified a combination of 2 human monoclonal antibodies (MAbs), CR57 and CR4098, that has high potential. We here describe a head-to-head comparison between an CR57/CR4098 MAb cocktail and HRIG. The MAb cocktail neutralized all viruses from a panel of 26 representative street rabies virus isolates. In combination with vaccine, the MAb cocktail protected Syrian hamsters against lethal rabies when administered 24 h after exposure, comparable with the results obtained with HRIG. Furthermore, the MAb cocktail did not interfere with rabies vaccine differently from HRIG. These results demonstrate that the human MAb cocktail of CR57 and CR4098 is a safe and efficacious alternative to RIG in rabies postexposure prophylaxis.


Related Articles

  • Generation and Characterization of an scFv Directed against Site II of Rabies Glycoprotein. Aavula, Shukra M.; Nimmagadda, Sridevi V.; Biradhar, Neelakantam; Sula, Samuel; Chandran, Dev; Lingala, Rajendra; Villuppanoor, Srinivasan Alwar // Biotechnology Research International;2011, p1 

    Recombinant antibody phage display technology is a vital tool that facilitates identification of specific binding molecules to a target enabling the rapid generation and selection of high affinity, fully human, or mouse antibody product candidates essentially directed towards disease target...

  • Animal Reservoirs of Rabies.  // Clinical Pediatrics;Jun1973, Vol. 12 Issue 6, p350 

    Focuses on the animal reservoirs of rabies in different parts of the world. Overview of the eradication of rabies in Great Britain; Observation that foxes provide the main reservoir from the eastern seaboard to the Appalachian Mountains; Claim that in the Midwest, Southwest and Far West, skunks...

  • Sequence Analysis of Rabies Virus in Humans Exhibiting Encephalitic or Paralytic Rabies. Hemachudha, Thiravat; Wacharapluesadee, Supaporn; Lumlertdaecha, Boonlert; Orciari, Lillian A.; Rupprecht, Charles E.; La-ongpant, Molruedee; Juntrakul, Sasiwimon; Denduangboripant, Jessada // Journal of Infectious Diseases;10/1/2003, Vol. 188 Issue 7, p960 

    Discusses a study which analyzed rabies virus in humans exhibiting encephalitic or paralytic rabies. Similarities in the deduced amino-acid patterns of the N protein in both human and canine rabies virus samples; Support on the concept that clinical manifestations of rabies are not explained...

  • Development of a Mouse Monoclonal Antibody Cocktail for Post-exposure Rabies Prophylaxis in Humans. Müller, Thomas; Dietzschold, Bernhard; Ertl, Hildegund; Fooks, Anthony R.; Freuling, Conrad; Fehlner-Gardiner, Christine; Kliemt, Jeannette; Meslin, Francois X.; Rupprecht, Charles E.; Tordo, Noël; Wanderler, Alexander I.; Kieny, Marie Paule // PLoS Neglected Tropical Diseases;Nov2009, Vol. 3 Issue 11, p1 

    As the demand for rabies post-exposure prophylaxis (PEP) treatments has increased exponentially in recent years, the limited supply of human and equine rabies immunoglobulin (HRIG and ERIG) has failed to provide the required passive immune component in PEP in countries where canine rabies is...

  • A Disease Most Awful. Williams, Ted // Audubon;Jul84, Vol. 86 Issue 4, p16 

    Chronicles the history of rabies virus in the United States. Overview on rabies outbreaks in the country; Dangers of raccoons to humans; Estimated number of reported cases of animal rabies; Use of vaccine cultured in duck embryos; Developing immunity from the disease.

  • Susceptibility and lack of evidence for a viremic state of rabies in the night owl monkey, Aotus nancymaae. Reaves, Erik J.; Salm¢n-Mulanovich, Gabriela; Guevara, Carolina; Kochel, Tadeusz J.; Steinbach, Thomas J.; Bentzel, David E.; Montgomery, Joel M. // Virology Journal;2012, Vol. 9 Issue 1, p95 

    Background: Rabies causes an acute fatal encephalomyelitis in most mammals following infection with rhabdovirus of the genus Lyssavirus. Little is known about rabies virus infection in species of New World non-human Primates (NHP). To investigate the suitability of the owl monkey Aotus nancymaae...

  • Comparison of Biotinylated Monoclonal and Polyclonal Antibodies in an Evaluation of a Direct Rapid Immunohistochemical Test for the Routine Diagnosis of Rabies in Southern Africa. Coetzer, Andre; Sabeta, Claude T.; Markotter, Wanda; Rupprecht, Charles E.; Nel, Louis H. // PLoS Neglected Tropical Diseases;Sep2014, Vol. 8 Issue 9, p1 

    The major etiological agent of rabies, rabies virus (RABV), accounts for tens of thousands of human deaths per annum. The majority of these deaths are associated with rabies cycles in dogs in resource-limited countries of Africa and Asia. Although routine rabies diagnosis plays an integral role...

  • Rabies — the need for a `one medicine' approach. Fooks, A. R. // Veterinary Record: Journal of the British Veterinary Association;9/1/2007, Vol. 161 Issue 9, p289 

    The article focuses on the future rabies control in the developing countries. The author implies that rabies remains a major threat to human health in Asia and Africa. He argues that given the role played by dogs as a reservoir and source of the disease, it is important that control strategy...

  • Forecasting the Path of a Raccoon Rabies Epidemic. Russell, C. A.; Smith, D. L.; Childs, J. E.; Real, L. A. // PLoS Biology;Mar2005, Vol. 3 Issue 3, p360 

    The article cites a study on predictive spatial dynamics and strategic planning for raccoon rabies emergence in Ohio. The study was conducted by researchers, C.A. Russell, D.L. Smith, J.E. Childs, L.A. Real. One strategy for limiting rabies spread is to establish vaccine corridors by...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics