TITLE

Preconceptional Primary Human Cytomegalovirus Infection and Risk of Congenital Infection

AUTHOR(S)
Revello, Maria Grazia; Zavattoni, Maurizio; Furione, Milena; Fabbri, Elisa; Gerna, Giuseppe
PUB. DATE
March 2006
SOURCE
Journal of Infectious Diseases;3/15/2006, Vol. 193 Issue 6, p783
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The risk of vertical transmission of human cytomegalovirus (HCMV) was investigated in 14 women who had primary HCMV infection 2-18 weeks before their last menstrual period during 2001-2004. One (8.3%) of 12 newborns examined at birth was found to be subclinically infected. Preconceptional primary HCMV infection has a transmission rate that is significantly higher than that observed in an unselected newborn population but significantly lower than that associated with maternal infection during pregnancy. Although a safe time interval between primary infection and initiation of pregnancy still needs to be defined, documented information can now be provided during counseling.
ACCESSION #
19979797

 

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